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Dose and LET Dependency of Bystander-Induced Micronucleation in Normal Human Fibroblasts
https://repo.qst.go.jp/records/71315
https://repo.qst.go.jp/records/713156a2563b6-17ef-4624-8d00-2d4d809e38f0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-28 | |||||
| タイトル | ||||||
| タイトル | Dose and LET Dependency of Bystander-Induced Micronucleation in Normal Human Fibroblasts | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Yoshitaka
× Matsumoto, Yoshitaka× Hamada, Nobuyuki× Aoko-Nakano, Mizuho× Wada, Seiichi× Funayama, Tomoo× Sakashita, Tetsuya× Usami, Noriko× Kakizaki, Takehiko× Kobayashi, Katsumi× Kobayashi, Yasuhiko× Furusawa, Yoshiya× 松本 孔貴× 宇佐美 徳子× 小林 克己× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | When cells were irradiated with ionizing radiation, non-irradiated cells around irradiated cells showed same biological effect, for example apoptosis, DNA damage, chromosomal aberration, and this phenomenon is called bystander effect. Bystander effect is caused by two major pathways. One is a gap junction signalling and the other is a medium-mediated signalling. The correlation of these pathways with bystander effect, and some transmission agents of this effect were reported in many papers. But the existence of the particle number-, dose or LET-dependency of this effect is still a matter of debate. In this experiment, we demonstrated that the dependency of bystander effect was observed in AG01522 cells exposed to photon or heavy-ion (carbon (120 keV/µm), neon (430 keV/µm) or argon (1260 keV/µm)) micro-beam, respectively. The bystander effect was estimated by the micronucleus (MN) formation which is a kind of a chromosome aberration. As the results, Ne- and Ar-ion beam with high-LET beams showed the bystander effects by only one particle irradiation, however the dose-dependency was not observed. C-ion beam with middle-LET showed the significant dose-dependency of bystander effect. On the other hand, X-ray micro-beam did not show the bystander effect as well as the dose-dependency. In summary, the bystander effect must have dose and LET dependency, however it is considered to be greatly dependent on some conditions, such as dose range, biological end point, radiation quality, and a kind of cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Micros 2013 16th International Symposium of Microdosimetry | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-25 | |||||
| 日付タイプ | Issued | |||||
