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Dose, LET and Ion Species Dependence for PLDR in Normal Human Embryo Fibroblasts
https://repo.qst.go.jp/records/71308
https://repo.qst.go.jp/records/713087e49f629-e2a4-4473-9a39-cc988ea04cea
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-23 | |||||
| タイトル | ||||||
| タイトル | Dose, LET and Ion Species Dependence for PLDR in Normal Human Embryo Fibroblasts | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
劉, 翠華
× 劉, 翠華× 鶴岡, 千鶴× アッサワプロンポーン, ナロンチャイ× 金子, 由美子× 村上, 健× 劉 翠華× 鶴岡 千鶴× アッサワプロンポーン ナロンチャイ× 金子 由美子× 村上 健 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In the present study, we conducted an-in deep study of the role of radiation quality (LET), radiation dose and ion species in modulating the PLDR in human cells exposed to low-or high-LET radiations. Cells were irradiated with various types of radiation and the LET values ranged from ~2.2 to 400 keV/um. Cell-killing efficiencies were measured using a colony-formation assay at immediately (IP, 5-10 min) or delayed plating (DP, 24 h) after irradiation. The PLDR was calculated by the ratio of surviving fractions (DP/IP) at different doses or isosurvival dose of IP. As expected, PLDR decreased with increase LET and when LET was higher than ~200keV/µm; there are little PLDR in all types of radiation and doses. Moreover, there are a minor PLDR in low-dose of all types of radiation used. Interestingly, the results showed that the PLDR of carbon ions is higher than that of helium ions, On the other hand the PLDR of Silicon is higher than other kinds of ions-beams comparing with similar LET radiations. Those results indicated that PLDR is not only depended on LET, but also dependent on radiation doses and ion species. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本放射線影響学会第56回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-20 | |||||
| 日付タイプ | Issued | |||||
