WEKO3
アイテム
Interaction of Mlh1 deficiency with radiation and/or mild inflammation in colon carcinogenesis in mice
https://repo.qst.go.jp/records/71278
https://repo.qst.go.jp/records/7127899da7190-4dfb-4bb3-bc47-133343276d81
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-10-07 | |||||
| タイトル | ||||||
| タイトル | Interaction of Mlh1 deficiency with radiation and/or mild inflammation in colon carcinogenesis in mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Morioka, Takamitsu
× Morioka, Takamitsu× Kakinuma, Shizuko× Nishimura, Mayumi× Imaoka, Tatsuhiko× Tokairin, Yutaka× Yamada, Yutaka× Yoshimi, Naoki× Shimada, Yoshiya× 森岡 孝満× 柿沼 志津子× 西村 まゆみ× 今岡 達彦× 東海林 裕× 山田 裕× 吉見 直己× 島田 義也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Both genetic and environmental factors play critical roles in colon carcinogenesis. The mutL homolog 1 (MLH1) gene, one of the DNA mismatch repair genes, is a main causal gene of hereditary nonpolyposis colorectal cancer (HNPCC). Ionizing radiation and colitis are also known risk factors for colorectal cancer. However, little is known about the interaction of these factors. Hence, we examined the combined effects of radiation and inflammation on colon carcinogenesis using Mlh1-deficient mice. Male and female 2- and 7-week-old Mlh1-/-, Mlh1+/- and Mlh1+/+ mice were irradiated with X-rays at a dose of 2 Gy. Then, they were treated with 1% dextran sodium sulfate (DSS) or vehicle in drinking water for 7 days at 10 weeks of age to induce inflammatory colitis. Colons were examined for tumors at the 14th week after the end of DSS treatment. We found more colon tumors after combined exposure of radiation with DSS, compared with single or no treatment in Mlh1-/- mice. But the effect was much less in Mlh1+/- or Mlh1+/+ mice. In conclusion, combined exposure of radiation with mild inflammation enhances colon carcinogenesis in homozygous Mlh1 mice. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第72回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2013-10-05 | |||||
| 日付タイプ | Issued | |||||
