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CONTRIBUTION OF INDIRECT ACTION IN HSG CELLS BY SOBP CARBON-ION BEAMS
https://repo.qst.go.jp/records/71237
https://repo.qst.go.jp/records/7123702a89528-7a2c-4245-a5e8-8423b917aac7
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-11 | |||||
| タイトル | ||||||
| タイトル | CONTRIBUTION OF INDIRECT ACTION IN HSG CELLS BY SOBP CARBON-ION BEAMS | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirayama, Ryoichi
× Hirayama, Ryoichi× Matsumoto, Yoshitaka× Uzawa, Akiko× Kaneko, Yumiko× Ozaki, Masakuni× Yamashita, Kei× Li, Huizi× Shirai, Toshiyuki× Furusawa, Yoshiya× 平山 亮一× 松本 孔貴× 鵜澤 玲子× 金子 由美子× 尾崎 匡邦× 山下 慶× 李 惠子× 白井 敏之× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cell inactivation by X-rays as well as heavy-ions is induced by a combination of direct and indirect actions. The aim of this study was to clarify the cell survival in human salivary gland (HSG) cells after 290 MeV/nucleon carbon-ion beams and X-rays. Moreover, the contribution of indirect action in cell inactivation can be estimated from the maximum degree of protection by dimethylsulfoxide (DMSO), which suppresses indirect action without affecting direct action. Irradiation with either carbon-ion beams with a 6-cm spread-out Bragg peak or 200kV X-rays was delivered to HSG cells. HSG cells were irradiated at six positions (plateau, middle, 25 mm upstream, 25 mm downstream, 28 mm downstream, and 35 mm downstream of middle position). Cell inactivation by carbon-ions and X-rays was measured by colony formation assay. The large RBE value (2.5) showed at the distal-end (28 mm downstream) in the SOBP. The contributions of indirect action decreased with the depth of the SOBP. That of indirect action for the SOBP beam at the distal-end was 65% +/- 2. That at plateau position was 86% +/- 9, and the value was very similar in X-rays (77% +/- 5). Interestingly, we could see the high contribution of indirect action to cell killing at the distal-end in SOBP carbon-ions, although RBE of 2.5 was shown. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 40th Annual Meeting of the European Radiation Research Society | |||||
| 発表年月日 | ||||||
| 日付 | 2013-09-05 | |||||
| 日付タイプ | Issued | |||||
