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Indirect action to cell killing by SOBP carbon-ion beams

https://repo.qst.go.jp/records/71113
https://repo.qst.go.jp/records/71113
59513173-8311-4587-98dc-1ad6d013635b
Item type 会議発表用資料 / Presentation(1)
公開日 2013-05-22
タイトル
タイトル Indirect action to cell killing by SOBP carbon-ion beams
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Hirayama, Ryoichi

× Hirayama, Ryoichi

WEKO 699002

Hirayama, Ryoichi

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Matsumoto, Yoshitaka

× Matsumoto, Yoshitaka

WEKO 699003

Matsumoto, Yoshitaka

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Uzawa, Akiko

× Uzawa, Akiko

WEKO 699004

Uzawa, Akiko

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Kaneko, Yumiko

× Kaneko, Yumiko

WEKO 699005

Kaneko, Yumiko

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Koda, Kana

× Koda, Kana

WEKO 699006

Koda, Kana

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Ozaki, Masakuni

× Ozaki, Masakuni

WEKO 699007

Ozaki, Masakuni

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Yamashita, Kei

× Yamashita, Kei

WEKO 699008

Yamashita, Kei

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Li, Huizi

× Li, Huizi

WEKO 699009

Li, Huizi

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Shirai, Toshiyuki

× Shirai, Toshiyuki

WEKO 699010

Shirai, Toshiyuki

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Furusawa, Yoshiya

× Furusawa, Yoshiya

WEKO 699011

Furusawa, Yoshiya

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平山 亮一

× 平山 亮一

WEKO 699012

en 平山 亮一

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松本 孔貴

× 松本 孔貴

WEKO 699013

en 松本 孔貴

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鵜澤 玲子

× 鵜澤 玲子

WEKO 699014

en 鵜澤 玲子

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金子 由美子

× 金子 由美子

WEKO 699015

en 金子 由美子

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尾崎 匡邦

× 尾崎 匡邦

WEKO 699016

en 尾崎 匡邦

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山下 慶

× 山下 慶

WEKO 699017

en 山下 慶

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李 惠子

× 李 惠子

WEKO 699018

en 李 惠子

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白井 敏之

× 白井 敏之

WEKO 699019

en 白井 敏之

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古澤 佳也

× 古澤 佳也

WEKO 699020

en 古澤 佳也

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抄録
内容記述タイプ Abstract
内容記述 The aim of this study was to clarify the cell survival in human salivary gland (HSG) cells after 290 MeV/nucleon carbon-ion beams and X-rays. Irradiation with either carbon-ion beams with a 6-cm spread-out Bragg peak or 200kV X-rays was delivered to HSG cells. HSG cells were irradiated at six positions (plateau, middle, 25 mm upstream, 25 mm downstream, 28 mm downstream, 35 mm downstream of middle position). Cell kill efficiencies of carbon-ions and X-rays were measured by colony formation assay. The contributions of OH radical mediated indirect action were estimated from the maximum degree of protection by DMSO, which suppresses indirect action without affecting direct action. The large RBE value (~2.5) showed at the distal-end (25 mm downstream) in the SOBP. The contributions of indirect action decreased with the depth of the SOBP. That of indirect action for the SOBP beam at the distal-end was 65% +/- 2. That at plateau position was 86% +/- 9, and the value was very similar in X-rays (77% +/- 5). Interestingly, we could see the high contribution of indirect action to cell killing at the distal-end in SOBP carbon-ions, although RBE of 2.5 was shown.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 Heavy Ion in Therapy and Space Radiation Symposium 2013 (HITSRS2013)
発表年月日
日付 2013-05-18
日付タイプ Issued
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