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Radical-Scavenging Reactions of Ascorbic Acid and Its Analogue in the Presence of a Redox-Inactive Metal Ion
https://repo.qst.go.jp/records/70993
https://repo.qst.go.jp/records/70993d16ae52d-7f82-4157-9b88-e21ff32aa610
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-11-21 | |||||
| タイトル | ||||||
| タイトル | Radical-Scavenging Reactions of Ascorbic Acid and Its Analogue in the Presence of a Redox-Inactive Metal Ion | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Inami, Keiko× Nomura, Shogo× Ohkubo, Kei× Kawashima, Tomonori× Mochizuki, Masataka× Fukuzumi, Shunichi× Ozawa, Toshihiko× Matsumoto, Kenichiro× 中西 郁夫× 川島 知憲× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ascorbic acid (AscH(2)) is an important naturally occurring, water-soluble antioxidant. However, the detailed radical-scavenging mechanism of AscH(2) has yet to be fully clarified. In this study, we investigated the radical-scavenging kinetics of AscH(2) and 5,6-isopropylidenen ascorbic acid (iAscH(2)) in the absence or presence of magnesium ion (Mg(2+)). AscH(2) efficiently scavenged galvinoxyl and 2,2-diphenyl-1-picrylhydrazyl radicals (GO radical and DPPH radical, respectively) in deaerated methanol (MeOH) at 298 K. The pseudo-first-order rate constants (k(obs)) determined for these reactions increased with increasing AscH(2) concentration to reach constant values. The k(obs) values were significantly decreased in the presence of 0.1 M Mg(ClO(4))(2). Similar results were obtained for the reactions of iAscH(2) with these radicals in deaerated MeOH as well as in deaerated acetonitrile (MeCN). The detailed radical-scavenging mechanisms will be discussed based on the kinetic data obtained in this study. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 19th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2012) | |||||
| 発表年月日 | ||||||
| 日付 | 2012-11-18 | |||||
| 日付タイプ | Issued | |||||
