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Hsp90 inhibitor may enhance the effectiveness of heavy ion treatment
https://repo.qst.go.jp/records/70929
https://repo.qst.go.jp/records/709294f2a03d9-2e32-4e45-beef-4996e387fe9f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-10-09 | |||||
| タイトル | ||||||
| タイトル | Hsp90 inhibitor may enhance the effectiveness of heavy ion treatment | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okayasu, Ryuichi
× Okayasu, Ryuichi× Hirakawa, Hirokazu× Noguchi, Miho× Hirayama, Ryoichi× Takahashi, Momoko× Fujimori, Akira× 岡安 隆一× 平川 博一× 野口 実穂× 平山 亮一× 高橋 桃子× 藤森 亮 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Due to its high relative biological effectiveness (RBE), heavy ion beams are thought to cause sufficient cellular damage to effectively kill cancer cells. However, even with high linear energy transfer (LET) heavy ion treatment, it may not be able to control all the tumor growth, and recurrence or metastasis might still occur. One strategy to cope with this situation is to combine heavy ion therapy with a chemical which further enhances biological effectiveness for tumor cell killing. We have studied the combination effect of carbon ions and hsp90 inhibitors in vitro and in vivo. SQ5 lung tumor cells were used to examine cell survival by colony formation assay and also used for mouse xenograft model. Our data indicate that tumor growth was better controlled both in vitro and in vivo with the combination of hsp90 inhibitor 17AAG and carbon ions than the carbon treatment alone. Since 17AAG was previously shown to inhibit the homologous recombination repair (HRR) pathway of DNA double strand breaks (DSBs) in cells exposed to X-rays, HRR was also thought to be affected in cells irradiated with carbon ions. As our preliminary data indicated that this might be the case as DSB rejoining after carbon ion exposure was less efficient with 17AAG pretreatment. We are further studying the mechanism of hsp 90 radiosensitization with heavy ions as well as the effect of other hsp 90 inhibitors if they reveal the similar effect when combined with heavy ions. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Radiation Research Society 58th Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2012-10-03 | |||||
| 日付タイプ | Issued | |||||
