WEKO3
アイテム
毒性伝達機構の分子イメージングを基軸とした神経変性疾患研究
https://repo.qst.go.jp/records/70906
https://repo.qst.go.jp/records/70906a2793c08-b443-4fa2-93b4-3fd822feda3d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-09-24 | |||||
| タイトル | ||||||
| タイトル | 毒性伝達機構の分子イメージングを基軸とした神経変性疾患研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
樋口, 真人
× 樋口, 真人× 樋口 真人 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The molecular pathogenesis of neurodegenerative diseases as exemplified by Alzheimer's disease is known to be triggered by deposition of proteinaceous aggregates in the brain, and this amyloid fibrillogenesis provokes chain reactions of key pathological processes including neuroinflammation and synaptic disruption. The primary goals of our in-vivo neuroimaging research are to track spatial dissemination of the amyloidosis over time and to clarify mechanistic links among these key processes by pharmacological and genetic approaches. Positron emission tomography (PET) allows the use of wide range of chemical probes targeting diverse biological molecules, while macroscopic assays using PET with a large field of view but relatively low spatial resolution require to be supplemented by mesoscopic and microscopic analyses such as MRI and optical imaging. We have developed multimodal imaging probes for amyloid-beta peptide (A beta) and tau fibrils applicable to PET and fluorescence optics, enabling visualization of pathological aggregates from cellular to regional scales. Intraneuronal and extraneuronal mechanisms regulating clearance, packaging and dissemination of these fibrillar assemblies have also been pursued with the aid of imaging systems. Ubiquitin-binding protein p62 and calcium-dependent cysteine protease calpain were identified as neuronal modulators of tau and A beta pathologies, respectively, and PET imaging of 18-kDa translocator protein revealed the implication of this molecule in neurotoxic conversion of microglia accelerating both tau and A beta pathogeneses. Finally, changes in the density and functionality of neuroreceptors have been examined in animal models of neurodegenerative proteinopathies by PET with specific probes. It is of particular significance that the release of neurotransmitters and crosstalk between different neuroreceptor systems are currently assessable by noninvasive imaging techniques. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 新学術領域研究「脳内環境」 H24年度夏の班会議 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-07-27 | |||||
| 日付タイプ | Issued | |||||
