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Heavy-ion microbeam system for cell irradiation at Kyoto
https://repo.qst.go.jp/records/70857
https://repo.qst.go.jp/records/70857cd168e89-05b0-446a-8014-53e3691cc907
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-08-27 | |||||
| タイトル | ||||||
| タイトル | Heavy-ion microbeam system for cell irradiation at Kyoto | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakamura, Masanobu
× Nakamura, Masanobu× Imai, Kenichi× Hirose, Masanori× Matsumoto, Hiroshi× Tozaki, Mitsuo× Ohsawa, Daisuke× Makino, Seiji× Tsunoyama, Yuichi× Isono, Mayu× Suya, Noriyoshi× Konishi, Teruaki× 酢屋 徳啓× 小西 輝昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Charged-particle microbeams can be used to irradiate individual cells with micron precision and with a precise number of charged particles. Heavy ions have peculiar biological effects on cells compare to other low LET radiation, due to their energy localization along the track. Thus, an investigation of biological effects of heavy ion near the Bragg peak becomes important. 8-MV tandem Van de Graaff accelerator at Kyoto University has been used for programs of heavy ion induced cellular response, which has been running from 2002 [1]. The collimation system was developed based on the system of Columbia University [2]. The final collimator consisted of a pair of apertures. A copper-alloy aperture was added to the downstream surface of the second aperture in order to reduce the effects of secondary radiation. Here, we present the accomplishment with 42-MeV carbon ion beam, which was extracted through the collimator to the atmosphere. Extracted ions were detected by a Si detector. When the number of signals from the detector exceeded a specified number, the beam is stopped by electrostatic beam deflector. The effectiveness of beam collimation and the control system was confirmed by observing tracks in irradiated thin CR-39 track detector located at the sample position. The pits were concentrated in the region of an approximately 8-MUm in diameter. To confirm whether the cells are hit by carbon ions, A549-pBOS-H2BGFP cells, which stably expressing histone H2B and GFP in the nuclei were targeted and were immuno-stained against GAMMA-H2AX, a marker for DNA double strand breaks. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th INTERNATIONAL CONFERENCE ON NUCLEAR MICROPROBE TECHNOLOGY & APPLICATIONS 2012 | |||||
| 発表年月日 | ||||||
| 日付 | 2012-07-27 | |||||
| 日付タイプ | Issued | |||||
