WEKO3
アイテム
Correction of head movement by frame-to-frame image realignment on human brain PET images with [11C]raclopride and [11C]FLB457
https://repo.qst.go.jp/records/70849
https://repo.qst.go.jp/records/708492760974b-95df-4f4d-bdf2-7fb1328c97aa
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-08-15 | |||||
| タイトル | ||||||
| タイトル | Correction of head movement by frame-to-frame image realignment on human brain PET images with [11C]raclopride and [11C]FLB457 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ikoma, Youko
× Ikoma, Youko× Kimura, Yasuyuki× Shiraishi, Takahiro× Suhara, Tetsuya× Ito, Hiroshi× 生駒 洋子× 木村 泰之× 白石 貴博× 須原 哲也× 伊藤 浩 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Positron emission tomography with [11C]raclopride and [11C]FLB457 has been utilized for imaging dopamine D2 receptors in the striatum and extrastriatum, respectively. PET scans with these ligands require 60-90 min consecutive acquisition for a quantitative analysis. Therefore, head movement is often observed during scanning, and it hampers the reliability of quantitative outcomes, especially for small brain structures. Image-based motion correction with frame-to-frame realignment is a practical method, since it dose not require motion information obtained by an online tracking system. However, frame-to-frame realignment for emission PET images causes a mismatch between the emission scan and transmission scan used for the attenuation correction, and it may result in the error of quantitative analysis. In the present study, optimal image-based motion correction method including the transmission scan was evaluated for PET studies with [11C]raclopride and [11C]FLB457, and investigated the effect of this correction method on quantitative analysis outcomes. Methods: In 60-min dynamic PET scan with [11C]raclopride and 90-min dynamic PET scan with [11C]FLB457, emission sinograms were reconstructed with or without attenuation correction. In the first method, 6 motion parameters (x-translation, y-translation, z-translation, roll, pitch, and yaw) were estimated frame-by-frame by realigning each frame of attenuation corrected image (AC) with a reference image using normalized mutual information [1]. Four kinds of images were used as the reference image for realignment, those are, summed image of all frames, summed image of the first 2 min, one frame image with high count, and MR image coregistered to PET summation image. Meanwhile, in the second method, motion parameters were estimated by realigning each frame of non-attenuation corrected images (NAC) by a similar way. Then µ-map obtained from a transmission scan was realigned using estimated motion parameters to correct a mismatch between the transmission and emission scans [2], and attenuation correction and reconstruction were performed sequentially. After motion correction, time-activity curves (TAC) for the striatum or frontal cortex were obtained. The binding potentials (BP) were estimated for these TACs by a simplified reference tissue model with the cerebellum as a reference region, and compared with BP estimates before the correction. Results: The motion correction using NAC images could realign each frame image to every reference images for both [11C]raclopride and [11C]FLB457 studies, and the mismatch between the emission and transmission scan was also corrected using estimated motion parameters. However, the motion correction using AC images did not realign each frame image. After the correction with NAC, a discontinuity of TACs in the striatum and frontal cortex was improved. In the subject with the large movement during PET scanning, BP value of the striatum increased about 25% after the motion correction. Conclusion: Head movement during the PET dynamic scan with [11C]raclopride and [11C]FLB457 could be accurately corrected by applying the image-based realignment to non-attenuation corrected images. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 9th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (NRM2012) | |||||
| 発表年月日 | ||||||
| 日付 | 2012-08-11 | |||||
| 日付タイプ | Issued | |||||
