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Effects of Carbon Ion Beams on Liver Cancer Stem-Like Cells and Its Comparison with X-rays

https://repo.qst.go.jp/records/70808
https://repo.qst.go.jp/records/70808
348f74a0-1a80-4edc-9420-177b2484ae8b
Item type 会議発表用資料 / Presentation(1)
公開日 2012-06-22
タイトル
タイトル Effects of Carbon Ion Beams on Liver Cancer Stem-Like Cells and Its Comparison with X-rays
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Sai, Sei

× Sai, Sei

WEKO 695668

Sai, Sei

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Oonishi, Kazuhiko

× Oonishi, Kazuhiko

WEKO 695669

Oonishi, Kazuhiko

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Yamada, Shigeru

× Yamada, Shigeru

WEKO 695670

Yamada, Shigeru

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Kamada, Tadashi

× Kamada, Tadashi

WEKO 695671

Kamada, Tadashi

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崔 星

× 崔 星

WEKO 695672

en 崔 星

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大西 和彦

× 大西 和彦

WEKO 695673

en 大西 和彦

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山田 滋

× 山田 滋

WEKO 695674

en 山田 滋

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鎌田 正

× 鎌田 正

WEKO 695675

en 鎌田 正

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抄録
内容記述タイプ Abstract
内容記述 To investigate whether a carbon ion beam has beneficial effects compared to X-rays by targeting putative cancer stem cells, human liver cancer stem-like cells sorted from HepG2 and Huh7 cells were treated with or without carbon ion or X-ray irradiation and then colony formation assay, spheroid formation assay, in vivo tumorigenesis analyses, FACS analysis, as well as gammaH2AX foci formation assay were performed. FACS analysis showed that the proportion of CD133+/CD90+, CD44+/ESA+ was more significantly enriched by X-rays compared to carbon-ion beam. CD133+/CD90+ and CD44+/ESA+ cells significantly have higher number of colony and spheroid compared to CD133-/CD90- and CD44-/ESA- cells. In addition, CD133+/CD90+ and CD44+/ESA+ cells have shown more potential to form tumors in SCID mice than CD133-/CD90- and CD44-/ESA- cells. Colony assay showed that CD133+/CD90+ and CD44+/ESA+ cells appeared to be radioresistant to both X-ray and carbon ion beam, but carbon beam was more effective at killing those of cancer stem-like cells. The number of gammaH2AX foci in CD44-/CD24- cells was higher than that of CD44+/CD24+ cells after irradiation with either X-ray or carbon ion beam. The number of gammaH2AX foci in CD44+/CD24+ cells was almost the same in the early time, but it persists for significantly longer in carbon ion beam irradiated cells compared to X-rays. In conclusion, CD133+/CD90+ and CD44+/ESA+ cells are putative liver cancer stem cells, and carbon ion beams induce prolonged DNA damage, therefore potentially have advantage by targeting liver cancer stem-like cells compared to X-rays.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 International Society for Stem Cell Research (ISSCR) 10 th Annual Meeting
発表年月日
日付 2012-06-16
日付タイプ Issued
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