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  1. 学会発表・講演等
  2. ポスター発表

Ikaros is a critical target during simultaneous exposure to X-rays and N-ethyl-N-nitrosourea in mouse T-cell lymphomagenesis

https://repo.qst.go.jp/records/70715
https://repo.qst.go.jp/records/70715
785c3176-724f-4f55-a1b1-e30933feaa35
Item type 会議発表用資料 / Presentation(1)
公開日 2012-03-14
タイトル
タイトル Ikaros is a critical target during simultaneous exposure to X-rays and N-ethyl-N-nitrosourea in mouse T-cell lymphomagenesis
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Hirano, Shinobu

× Hirano, Shinobu

WEKO 694597

Hirano, Shinobu

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Kakinuma, Shizuko

× Kakinuma, Shizuko

WEKO 694598

Kakinuma, Shizuko

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Amasaki, Yoshiko

× Amasaki, Yoshiko

WEKO 694599

Amasaki, Yoshiko

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Nishimura, Mayumi

× Nishimura, Mayumi

WEKO 694600

Nishimura, Mayumi

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Imaoka, Tatsuhiko

× Imaoka, Tatsuhiko

WEKO 694601

Imaoka, Tatsuhiko

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Fujimoto, Shinji

× Fujimoto, Shinji

WEKO 694602

Fujimoto, Shinji

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Hino, Okio

× Hino, Okio

WEKO 694603

Hino, Okio

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Shimada, Yoshiya

× Shimada, Yoshiya

WEKO 694604

Shimada, Yoshiya

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坂入 しのぶ

× 坂入 しのぶ

WEKO 694605

en 坂入 しのぶ

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柿沼 志津子

× 柿沼 志津子

WEKO 694606

en 柿沼 志津子

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甘崎 佳子

× 甘崎 佳子

WEKO 694607

en 甘崎 佳子

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西村 まゆみ

× 西村 まゆみ

WEKO 694608

en 西村 まゆみ

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今岡 達彦

× 今岡 達彦

WEKO 694609

en 今岡 達彦

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島田 義也

× 島田 義也

WEKO 694610

en 島田 義也

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抄録
内容記述タイプ Abstract
内容記述 Cancer risk of radiation in humans is considered to result from simultaneous exposure to radiation and chemicals carcinogens. But its molecular mechanisms is insufficient. In this study, using a mouse thymic lymphoma (TL) model synergistically induced by simultaneous exposure to X-rays and N-ethyl-N-nitrosourea (ENU) at sub-carcinogenic doses, we analyzed the mutation of the TL-associated genes Ikaros, Notch1, p53, and Kras.
Beginning at 4 weeks of age, female B6C3F1 mice were weekly exposed to X-rays at 0.8, 1.0 or 1.2 Gy and given ENU at 100 or 200 ppm for 4 consecutive weeks at the same time. Collected TLs were examined for molecular analyses.
The point mutation frequency of Ikaros was 47% for simultaneous exposure, whereas 13% and 0% for X-ray and ENU exposure, respectively. These were mostly G:C > A:T at non-CpG sites and T:A > C:G characteristic of ENU mutagenesis. About half of the point mutations were accompanied by loss of heterozygosity (LOH), typical of X-rays. The remains did not include LOH, suggesting dominant-negative mutations. Abnormality frequency of Notch1 was high regardless of the treatment, but those of p53 and Kras were low. Importantly, the frequency of TLs containing mutations in both Ikaros and Notch1 increased after simultaneous exposure. Thus, in TL after simultaneous exposure, Ikaros is a critical target and inactivated by ENU-induced point mutations and X-ray-induced LOH. Furthermore, concomitant alterations of TL-associated genes may contribute to extreme lymphomagenesis.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 順天堂大学大学院医学研究科3年次ポスターセッション
発表年月日
日付 2012-03-06
日付タイプ Issued
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