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Involvement of BRCA1-interacting helicase BRIP1 during acinar morphogenesis of mammary epithelial cells in a three-dimensional basement membrane culture
https://repo.qst.go.jp/records/70669
https://repo.qst.go.jp/records/706690d0d6cd7-fb14-4338-a2a5-c498c6d5c638
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-01-11 | |||||
| タイトル | ||||||
| タイトル | Involvement of BRCA1-interacting helicase BRIP1 during acinar morphogenesis of mammary epithelial cells in a three-dimensional basement membrane culture | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
臺野, 和広
× 臺野, 和広× 今岡, 達彦× 西村, まゆみ× 島田, 義也× 臺野 和広× 今岡 達彦× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BRIP1 is a DNA helicase that directly interacts with the C-terminal BRCT repeat of the breast susceptibility protein BRCA1 and plays an important role in BRCA1-dependent DNA repair and DNA damage-induced checkpoint control. Recent studies implicate BRIP1 as moderate/low penetrance breast cancer susceptibility gene. However, the phenotypic effects and their molecular basis involved in the tumorigenesis of breast cancer due to the dysfunction of BRIP1 remain unclear. In this study, we generated BRIP1 knockdown mammary epithelial cells, to investigate a role of this gene in the mammary gland morphogenesis. Knockdown of BRIP1 in MCF-10A cells by RNA interference induced neoplastic-like changes such as abnormal cell adhesion, increased acinar size, irregular-shaped acinar structure, and invasive growth. Dysregulation of multiple genes in the knockdown cells was revealed by microarray analysis. These results suggest that BRIP1 is involved in the development of mammary glands through multiple genes and signaling pathways. Our results also provide, in part, the molecular basis involved in the tumorigenesis of breast cancer due to the dysfunction of BRIP1. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第34回日本分子生物学学会年会 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-12-16 | |||||
| 日付タイプ | Issued | |||||
