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Neuronal dysfunction in cingulate area in maternal immune activation rodent model of schizophrenia.
https://repo.qst.go.jp/records/70660
https://repo.qst.go.jp/records/706609e9ec51a-85b0-4ca7-82bd-59ef47fe7ab0
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-12-12 | |||||
| タイトル | ||||||
| タイトル | Neuronal dysfunction in cingulate area in maternal immune activation rodent model of schizophrenia. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oh-Nishi, Arata
× Oh-Nishi, Arata× et.al× 大西 新 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Schizophrenia is characterized by disturbances of thoughts, perception, cognition and volition. It is reported that about 1% of the world population becomes morbid with schizophrenia. it was reported that D2R ligand binding decreases in the cingulate (Cg) in schizophrenia patients (Suhara et al 2002) by positron emission tomography (PET) study. However, the neuronal pathology of Cg in schizophrenia is not well known. Here we investigated the Cg pathology in maternal immune activation rodent model of schizophrenia by In Vivo and In Vitro analysis. We gave Poly I:C (Sigma P9582: 4mg/kg/day, I.P.) to pregnant rats on gestation days 15-18, which led to increased IL-6, TNF-alpha and IL-1beta but not IL-2 and IL-10 in the maternal serums 3 hours after injection. We then investigated the neuronal function in Cg in mature offspring (12-16 weeks) of the Poly I:C-treated dams (Poly IC rats). Using micro PET, we found that dopamine D2 receptor (D2R) -specific ligand binding potential was significantly decreased in the Cg in Poly IC rats (P<0.003). Abnormal cognitive and/or emotional behavior was observed in these Poly IC rats by behavioral test. The results indicated a high degree of homology between the rodent model of maternal immune activation pathology and schizophrenia patients. Furthermore, we investigated neuronal pathology in the Cg area of the Poly IC rats. The number of Parvalbumin-positive cells (P<0.005) but not NeuN-positive cells was reduced in the Poly IC rats. The D2R exist Parvalbumin-positive interneuron in prefrontal cortex (Khan et al 1998, 2001) . In context, The decreasing number of parvalbumin-positive cell might lead to the reduction of D2R-specific ligand binding potential in the Cg of Poly IC rat. We suggest that number of interneuron might reduce in the Cg in schizophrenia patient arising from maternal immune activation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SFN 2011 | |||||
| 発表年月日 | ||||||
| 日付 | 2011-11-16 | |||||
| 日付タイプ | Issued | |||||
