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Synthesis and Radical-Scavenging Activity of Planar Catechin Derivatives with Various Amino Acids as a Promising Antioxidant
https://repo.qst.go.jp/records/70656
https://repo.qst.go.jp/records/706569638ea72-ab32-4be4-8fd2-a6fbce9a6206
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2011-12-05 | |||||
タイトル | ||||||
タイトル | Synthesis and Radical-Scavenging Activity of Planar Catechin Derivatives with Various Amino Acids as a Promising Antioxidant | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Imai, Kohei
× Imai, Kohei× Nakanishi, Ikuo× Nakanishi, Satomi× Takagaki, Ryohei× Ozawa, Toshihiko× Okuda, Haruhiro× Miyata, Naoki× Matsumoto, Kenichiro× Nakamura, Asao× Fukuhara, Kiyoshi× 中西 郁夫× 松本 謙一郎 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Radical-scavenging reactivities of newly synthesized 7 planar catechin derivatives substituted by an amino acid, which is lysine, arginine, histidine, asparagine acid, glutamic acid, serine, or cysteine, have been examined by the quenching kinetics of galvinoxyl radical in an acetonitrile solution observed by stopped flow technique. Among the derivatives, one bearing arginine moiety showed an approximate 670-fold enhanced radical-scavenging activity than naturally occurring (+)-catechin, which is due to the strong intramolecular hydrogen bonding between the amino acid and catechin moieties. | |||||
会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 8th AFMC International Medicinal Chemistry Symposium (AIMECS 11) | |||||
発表年月日 | ||||||
日付 | 2011-12-02 | |||||
日付タイプ | Issued |