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In vivo evaluation of a 18kDa translocator protein (TSPO/PBR) ligand [11C]AC-5216 in Alzheimer's disease mouse models
https://repo.qst.go.jp/records/70584
https://repo.qst.go.jp/records/7058419f8cd84-04ac-4732-a47f-b63936564738
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-20 | |||||
| タイトル | ||||||
| タイトル | In vivo evaluation of a 18kDa translocator protein (TSPO/PBR) ligand [11C]AC-5216 in Alzheimer's disease mouse models | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Maeda, Jun
× Maeda, Jun× Zhang, Ming-Rong× Ki, Hin× Okauchi, Takashi× Fukumura, Toshimitsu× Suhara, Tetsuya× Higuchi, Makoto× 前田 純× 張 明栄× 季 斌× 岡内 隆× 福村 利光× 須原 哲也× 樋口 真人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Fibrillary lesions composed of amyloid-beta; peptides (Abeta) and tau are pathological hallmarks of Alzheimer's disease (AD), and tau aggregates are also characteristic of non-AD tauopathies. These amyloid deposits were inevitably accompanied by microglial activation, which has been noninvasively visualized by recent advances in positron emission tomographic (PET) imaging with the aid of radiolabeled ligands for the peripheral benzodiazepine receptor also known as the 18-kDa translocator protein (TSPO). In the present study, we examined the performance and significance of new TSPO imaging agent, [11C]AC-5216, for pursuing roles of microglia in Abeta; and tau pathogeneses and for diagnostic and therapeutic evaluations of neuroinflammation in AD and related disorders. Immunostaining of TSPO in AD and non-AD tauopathy brains demonstrated an intimate association between TSPO-positive microglia and tau inclusions, and microglial TSPO upregulation antecedent to massive neuronal death was also observed in living tau transgenic mice by means of [11C]AC-5216-PET. A tight correlation between in vitro autoradiographic signals of [11C]AC-5216 and phorphorylated tau burden was found even prior to the emergence of mature tau fibrils detectable with thioflavin-S. Unlike tau-induced TSPO-positive microgliosis, TSPO levels in aged amyloid precursor protein transgenic mice were only modestly increased. This was in sharp contrast with notable Abeta; accumulation in these animals as imaged by an amyloid radioligand, [11C]Pittsburgh Compound-B. These results indicate the usefulness of [11C]AC-5216 in quantitative mapping of tau-provoked toxic neuroinflammation, and support the applicability of PET imaging with this radiotracer to clinical assessments of diverse tauopaties including AD | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | World Molecular Imaging Congress 2010 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-11 | |||||
| 日付タイプ | Issued | |||||
