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アイテム
Lifespan shortening after exposure of mice at fetal, childhood and adulthood periods to gamma-rays and carbon ions
https://repo.qst.go.jp/records/70559
https://repo.qst.go.jp/records/70559f0f7fd1c-fedf-42e2-867f-a31c318e943e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-10-05 | |||||
| タイトル | ||||||
| タイトル | Lifespan shortening after exposure of mice at fetal, childhood and adulthood periods to gamma-rays and carbon ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kakinuma, Shizuko
× Kakinuma, Shizuko× Shang, Yi× Amasaki, Yoshiko× Hirano, Shinobu× Sawai, Tomoko× Nishimura, Mayumi× Takabatake, Takashi× Takahashi, Erika× Yamauchi, Kazumi× Nakata, Akifumi× Takimoto, Misaki× Sawa, Yurika× Imaoka, Tatsuhiko× Shimada, Yoshiya× 柿沼 志津子× 尚 奕× 甘崎 佳子× 坂入 しのぶ× 澤井 知子× 西村 まゆみ× 高畠 貴志× 高橋 江里佳× 山内 一己× 中田 章史× 滝本 美咲× 澤 百合香× 今岡 達彦× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: There are insufficient data at present on cancer risk after exposure of heavy ions, to the fetal and childhood periods. Using animal models, we studied the age-at-exposure effects of heavy ions on cancer induction and lifespan shortening for radiation protection for fetuses and children. \nMaterials and Methods: Fifty female and male B6C3F1 mice per group were exposed to gamma rays (137Cs) or carbon ions (13 keV/µm) at various ages from fetal to mature adulthood periods. Mouse ages at the time of irradiation included pre-implantation (3 days post-conception (dpc)), major organogenesis (13 dpc), late fetal (17 dpc), neonatal (1 week after birth), infantile (3 weeks), young adulthood (7 weeks) and mature adulthood stages (15 weeks). The doses ranged between 0.2 and 4 Gy for gamma rays and 0.2 and 2 Gy for carbon ions. The mice were observed until moribund and their lifespan and the developed cancers were analyzed. \nResults and Discussion: Our study indicated that female mice appeared to be more susceptible to radiation-induced lifespan shortening than male mice. Effect of gamma-rays on lifespan shortening was more manifested when irradiated at neonatal than adult stage. Surprisingly, irradiation with gamma rays at the late fetal stage had little influence on lifespan shortening compared to infant and adulthood exposures. On the other hand, carbon ions were more potent in reducing lifespan than gamma rays when female neonatal mice were exposed. When carbon ions were exposed, however, fetuses were as susceptible as infants. The results on the lifespan shortening suggest a larger RBE of carbon ions for fetuses than later stages. The RBE of carbon ions for reducing the tumor-free survival rate was ~1.0 for fetuses, suggesting that RBE of 13keV/µm carbon for cancer induction is 1.0 ~ 1.5 irrespective of age-at-exposure. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 14th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2011-09-01 | |||||
| 日付タイプ | Issued | |||||
