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Alteration of dopaminergic function in a primate model of hypothyroidism revealed by PET
https://repo.qst.go.jp/records/70547
https://repo.qst.go.jp/records/705474c76ace6-d401-4d8f-b91d-397b72039139
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-09-26 | |||||
| タイトル | ||||||
| タイトル | Alteration of dopaminergic function in a primate model of hypothyroidism revealed by PET | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yukiko, Hori
× Yukiko, Hori× Nagai, Yuji× Oh-Nishi, Arata× Suhara, Tetsuya× Minamimoto, Takafumi× 堀 由紀子× 永井 裕司× 大西 新× 須原 哲也× 南本 敬史 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Motivation toward action is affected by predicted outcome (e.g., reward size), desire for the outcome (e.g., hunger or thirst), as well as mood of the subject. Our previous study indicated that low motivational state is characterized by instrumental task performance in a monkey model of hypothyroidism, which is associated with symptoms of fatigue or depression (Minamimoto et al., 2010, Soc. Neurosci. Abstr). It has been shown that performance of goal-directed action is affected by dopaminergic manipulations (e.g., lesion or drug). We hypothesized that hypothyroidism induces dysfunctions of the dopaminergic system, which in turn lead to low motivation. Here, we studied dopamine receptor density in hypothyroidism model monkeys using positron emission tomography (PET). PET scan data were obtained with [11C]FLB457 (high affinity for extrastriatal D2 receptors) for both pre-hypothyroid control and hypothyroid state. Hypothyroid state was defined as when the monkey's thyroxin level reached less than 2 micro g/dl continuously after administration of antithyroid agent (methimazole, 100 mg/day) for 2 months. The subtraction image of [11C]FLB457 of control from hypothyroidism revealed the binding potential of D2 receptors as being increased specifically in the ventromedial prefrontal cortex (VMPFC). This result suggests that the upregulation of D2 receptors occurred by the decrease of dopamine release in VMPFC in hypothyroidism, resulting in low motivation for task performance. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第34回日本神経科学大会（Neuro2011） | |||||
| 発表年月日 | ||||||
| 日付 | 2011-09-17 | |||||
| 日付タイプ | Issued | |||||
