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Mammary carcinogenesis after exposure of fetal, neonatal, juvenile and adult rats to gamma rays and carbon ions
https://repo.qst.go.jp/records/70516
https://repo.qst.go.jp/records/70516efd15042-3be3-48a9-9468-9fe001a7abba
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-09-06 | |||||
| タイトル | ||||||
| タイトル | Mammary carcinogenesis after exposure of fetal, neonatal, juvenile and adult rats to gamma rays and carbon ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Nishimura, Mayumi× Daino, Kazuhiro× Iizuka, Daisuke× Kokubo, Toshiaki× Nishimura, Yukiko× Okutani, Tomomi× Takabatake, Masaru× Kakinuma, Shizuko× Takabatake, Takashi× Shang, Yi× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 臺野 和広× 飯塚 大輔× 小久保 年章× 西村 由希子× 奥谷 倫未× 高畠 賢× 柿沼 志津子× 高畠 貴志× 尚 奕× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The risk of developing secondary cancer after radiotherapy, especially after the treatment of childhood cancers, has been a matter of great concern. Epidemiologic studies have suggested that the breast is one of the most susceptible organs to radiation-induced carcinogenesis. However, little information is available on the effect of carbon ion radiation on breast carcinogenesis in children. Method: Female Jcl:SD Sprague-Dawley rats were whole body–irradiated with 1 Gy of Cs-137 g rays or a monoenergetic carbon ion beam (290 MeV/u, having LET of ~13 keV/mm) at various ages from the embryonic stage to adulthood. Neonatal, juvenile and young adult rats (1, 3 and 7 weeks of age, respectively) were irradiated with g rays or monoenergetic carbon ions at various doses between 0.2 and 2 Gy. The rats were observed until 90 weeks of age. Kaplan-Meier curves of the time until mammary carcinoma palpation were analyzed by the logrank method to calculate hazard ratios. Results: The hazard ratio for mammary carcinoma development tended to increase in groups of rats irradiated with 1 Gy of either g rays or carbon ions at ages between 1 and 7 postnatal weeks; irradiation of fetal rats with either radiation did not increase the ratio. Irradiation of neonatal rats at 2 Gy led to early cessation of regular estrous cycling. Dose responses of g rays were similar among the groups of rats irradiated at 1, 3 and 7 weeks of age. The effect of heavy ions tended to increase along with the age at the time of irradiation, indicating RBE values of 0.2, 1.2 and 2.5 for irradiation at 1, 3 and 7 weeks of age, respectively. Conclusion: The carcinogenic effect of carbon ion irradiation on mammary gland depends on the age at the time of exposure. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 14th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2011-09-01 | |||||
| 日付タイプ | Issued | |||||
