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Radiosensitivity in mesothelioma cell lines in X rays and carbon-ion beams
https://repo.qst.go.jp/records/70500
https://repo.qst.go.jp/records/7050008976311-3a64-468c-b04f-72925955bcdd
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-09-05 | |||||
| タイトル | ||||||
| タイトル | Radiosensitivity in mesothelioma cell lines in X rays and carbon-ion beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hua, Liu Cui
× Hua, Liu Cui× Suzuki, Masao× Autsavapromporn, Narongchai× Wada, Mami× Kaneko, Yumiko× et.al× 劉 翠華× 鈴木 雅雄× アッサワプロンポーン ナロンチャイ× 和田 麻美× 金子 由美子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE:Malignant pleural mesothelioma (MPM) is an aggressive tumor arising from serous surfaces and often related to asbestos exposure. Taking into account a latency period of 20-40 years, it has been estimated that the number of men dying from MPM increase each year until a peak is reached in about 2020. MPM is resistant to various forms of therapy, such as radiotherapy, surgery or chemotherapy, and only slightly improve prognosis. So far, no effective therapeutics including chemotherapy or radiotherapy has been established for the disease-advanced case. The present study was carried out in order to examine the radio-sensitivity of MPM cell lines by X rays and carbon-ion beams. MATERIALS AND METHODS: Six kinds of MPM cell lines officially distributed by the cell bank were used and irradiated with X rays or carbon-ion beams (13.3keV/µm and approximately 80keV/µm) at the Heavy Ion Medical Accelerator in Chiba (HIMAC) in National Institute of Radiological Sciences (NIRS), Japan. Cell-killing effect was detected using a colony-formation assay. RESULTS: D10, which is one of the parameters for cellular radio-sensitivity and is determined as the dose (Gy) required to reduce the surviving fraction to 10%, of 6 cell lines ranged from 2.74Gy to 5.42Gy for X rays, 2.17Gy to 4.21Gy for 13keV/µm- and 1.08Gy to 2.38Gy for 80keV/µm-carbon ions. The relative biological effectiveness (RBE) values were calculated by the D10 relative to X rays, ranged from 1.24 to 1.42 for 13keV/µm- and from 2.31 to 3.09 for 80keV/µm-carbon ions on each cell line. CONCLUSION: The results suggest that the irradiation of high-LET carbon ions is also significantly more effective in cell killing for the 6 kinds of MPM cell lines than that of low-LET X rays. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 14th International Congress of Radiation Research (ICRR’2011) | |||||
| 発表年月日 | ||||||
| 日付 | 2011-09-01 | |||||
| 日付タイプ | Issued | |||||
