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A case-control study to detect genetic and acquired risk factors for pediatric inflammatory bowel disease
https://repo.qst.go.jp/records/70488
https://repo.qst.go.jp/records/704887cc0df72-a337-4a1c-af23-5f3dd774d525
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-08-17 | |||||
| タイトル | ||||||
| タイトル | A case-control study to detect genetic and acquired risk factors for pediatric inflammatory bowel disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kobashi, Gen
× Kobashi, Gen× 小橋 元 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction:Pediatric inflammatory bowel disease(PIBD) is considered to be a multifactorial disease with both genetic and acquired factors involved in its etiology. THe acquired factors include lifestyles and environmental factors of both patients in pediatric period and their mothers in perinatal period. Parental smoking, not breast-feeding(human milk substitite), mental atress, lack of sleeping time, low body activity, appendectomy, preterm delivery, and some genetic variants concerning pathways of immune responses such as CARD15/NOD2, DLG5, TLR4, OCTN1/2, MYO9B, IL23R, ATG16L, have reported to be possible risk factors for PIBD. However, to date, there has been no study analyzing these factors simultaneously and clarifying their confoundings. The present study tries to elucidate genetic and acquired risk factors for PIBD and their confounding. Methods:PIBD cases and controls were recruited from affiliated hospital of the Japan workshop for pediatric inflammatory bowel disease. Saliva sample of patients for genotyping and self-administrated questionnaire for their motjers were obtained with written informed-consent. Result and conclusion:This paper will report interim results of the study starting from 2011. The present study is expected to develop early and individualized measures to prevent PIBD, intervention for lifestyles and environmental factors of expectant mothers possessing genetic risk factors for baby's future PIBD manifestation. Future, the results may contribute to clarify new pathogenesis of PIBD manifestation and more useful disease classification. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | IEA World Congress of Epidemiology | |||||
| 発表年月日 | ||||||
| 日付 | 2011-08-11 | |||||
| 日付タイプ | Issued | |||||
