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Insufficiency Fractures after Pelvic Radiotherapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG)
https://repo.qst.go.jp/records/70392
https://repo.qst.go.jp/records/70392ba99cbb3-c049-4952-a937-372fa721a105
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-02-02 | |||||
| タイトル | ||||||
| タイトル | Insufficiency Fractures after Pelvic Radiotherapy for Uterine Cervical Cancer: An Analysis of Subjects in a Prospective Multi-institutional Trial, and Cooperative Study of Japan Radiation Oncology Group (JAROG) and Japanese Radiation Oncology Study Group (JROSG) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tokumaru, Sunao
× Tokumaru, Sunao× Toita, Takafumi× Kato, Shingo× Niibe, Yuzuru× Kazumoto, Tomoko× Kodaira, Takeshi× Kataoka, Masaaki× Ohno, Tatsuya× Oguchi, Masahiko× Hiraoka, Masahiro× 加藤 眞吾× 古平 毅× 大野 達也× 小口 正彦× 平岡 真寛 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose/Objective(s): To investigate the pelvic insufficiency fractures (IF) post definitive pelvic radiotherapy for early stage uterine cervicalcancer, we analyzed the subject in a prospective multi-institutional study (JAROG0401/ JROSG04-2). \nMaterials/Methods: Between September 2004 and July 2007, 59 eligible patients, all Japanese, were enrolled. Median age was 73 years (range:37-84 years). The eligible patients had squamous cell carcinoma of the uterine cervix, and FIGO stages were Ib1: 35, IIa: 12, IIb: 12, and no pelvic/paraaortic lymphadenopathy. Protocol treatment consisted of whole pelvic external beam radiotherapy of 50 Gy/25 fractions and high-dose-rate intracavitary brachytherapy of 24 Gy/4 fractions (at point A) without chemotherapy. After radiotherapy, the patients were evaluated by both pelvic CT and pelvic MRI at 3, 6, 12, 18, and 24 months. Diagnosis of the IF was made when the patients had both CT and MRI findings, neither recurrent tumor lesions nor traumatic histories. CT findings of IF were defined as fracture lines or sclerotic linear changes in the bones, and MRI findings of IF were defined as the signal intensity changes in the bones, both on T1 and T2 weighted images. The patients also evaluated by CTCAE (Common Terminology Criteria for Adverse Events)-v.3.0 every 3 months from 3 until 30 months. \nResults: Median follow-up was 24 months (range: 3-30 months). The 2-year pelvic IF cumulative occurrence rate was 36% (21pts). On CTCAE-v3.0, G1, G2 and G3 were seen in 12 pts (20%), 6 pts (10%), and 3 pts (5%), respectively. Sixteen patients had multiple fractures, so the IF were identified at 44 sites. The pelvic IF were frequently seen at the ileo-cecal joints (32 sites: 72%),and at the pubes (9 sites: 20%). Nine patients complained of pelvic or back pains. All patients' pains were palliated by non-narcotic analgesic drugs. No patients needed surgical intervention. The higher age (>70y) was thought to be a risk factor of pelvic IF (p=0.03, log-rank test). \nConclusions: Older cervical cancer patients received pelvic radiotherapy may have some risks to develop pelvic IF. However, less than a half of the patients with IF complained of pains, and the pains caused by IF were treated effectively by non-narcotic analgesic drugs. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 52nd ASTRO Annual meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2010-11-04 | |||||
| 日付タイプ | Issued | |||||
