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pH dependent reaction of nitroxyl radicals and glutathione
https://repo.qst.go.jp/records/70387
https://repo.qst.go.jp/records/70387c6f9e279-3087-423c-84fe-14f0257385cc
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-01-24 | |||||
| タイトル | ||||||
| タイトル | pH dependent reaction of nitroxyl radicals and glutathione | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Kenichiro
× Matsumoto, Kenichiro× Nakanishi, Ikuo× Krishna, Murali× 松本 謙一郎× 中西 郁夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nitroxyl radicals were utilized as redox probe in a field of in vivo EPR spectroscopy and imaging. Recently, utility of nitroxyl radicals as redox sensitive contrast agents for functional MRI were proposed and were getting interests. Detail reaction of nitroxyl radicals with each biological molecule, such as glutathione (GSH), were however not enough investigated. In this study, pH dependence of reaction of nitroxyl radicals with GSH was investigated. Five deferent nitroxyl radicals, i.e. TEMPO, TEMPOL, TEMPONE, carbamoyl-PROXYL, and carboxy-PROXYL, were tested for comparison. It was appeared that reaction of nitroxyl radicals and GSH were faster at pH5.8 and slower at pH8.0 compared with pH7.0, except that carboxy-PROXYL did not show reduction at pH5.8.Introduction. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | International Symposium on Free Radical Research: Contribution to Medicine | |||||
| 発表年月日 | ||||||
| 日付 | 2011-01-22 | |||||
| 日付タイプ | Issued | |||||
