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Effects of Metal Ions on the Radical-Scavenging Reactions by Curcumin
https://repo.qst.go.jp/records/70379
https://repo.qst.go.jp/records/703799209e891-d27f-4498-968d-64ca037bb4e4
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-01-05 | |||||
| タイトル | ||||||
| タイトル | Effects of Metal Ions on the Radical-Scavenging Reactions by Curcumin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kawashima, Tomonori
× Kawashima, Tomonori× Ohkubo, Kei× Fukuhara, Kiyoshi× Ozawa, Toshihiko× Anzai, Kazunori× Fukuzumi, Shunichi× Nakanishi, Ikuo× 川島 知憲× 安西 和紀× 中西 郁夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Curcumin, a main and the most important yellow color component of turmeric, has been found to show antitumor and strong antioxidative activities. Antioxidative activity of CU is believed to be due to two 4-propenylphenol moieties in its molecule. On the other hand,CU also possesses an enolic structure, which may interact with metal ions in biological systems. A complex formation between CU and metal ions may affect the electron distribution in the CU molecule, resulting in change in the radical-scavenging activity of CU. In this study, we report to clarify the effect of metal ions on the radical-scavenging activity between CU. When CU was added to an acetonitrile (MeCN) solution of 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•), the absorption band at 519 nm due to DPPH• immediately decreased. This suggests that DPPH• is efficiently scavenged by <B>CU</B>. The scavenging rate constant (k) of DPPH• by CU was determined as 3.2 x 10<sup>2</sup> M<sup>–1</sup> s<sup>–1</sup> by the stopped-flow technique at 298 K. However, the k value was significantly decreased in the presence of 0.1 M Mg(ClO4)2 (<i>k</i> = 2.0 x 10 M-1 s-1), suggesting that CU interacts with magnesium ion (Mg2+). In fact, the spectral change was observed upon addition of Mg(ClO4)2 into the MeCN solution of CU. From the absorbance change at 441 nm was determined the binding constant (KM) between CU and Mg2+ as 3.0 x 102 M-1. Thus, the radical-scavenging activity of the Mg<sup>2+</sup> complex of CU may be lower than that of CU. Effects of other bio-related metal ions on the radical-scavenging reaction of CU will also be discussed in this study. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010) | |||||
| 発表年月日 | ||||||
| 日付 | 2010-12-20 | |||||
| 日付タイプ | Issued | |||||
