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In vivo redox status in rat bile and blood under oxygenated atmosphere
https://repo.qst.go.jp/records/70370
https://repo.qst.go.jp/records/70370a482bad3-cde8-4054-9e24-a77ebe6a8a0d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-21 | |||||
| タイトル | ||||||
| タイトル | In vivo redox status in rat bile and blood under oxygenated atmosphere | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okajo, Aya
× Okajo, Aya× Ui, Iori× Manda, Sushma× Nakanishi, Ikuo× Matsumoto, Kenichiro× Anzai, Kazunori× Endo, Kazutoyo× Ｍａｎｄａ Ｓｕｓｈｍａ× 中西 郁夫× 松本 謙一郎× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nitroxyl radicals have been utilized as tissue redox probes in fields of in vivo electron paramagnetic resonance (EPR). Distributions and time courses of a nitroxyl contrast agent obtained by an in vivo EPR technique can give information about the redox status in target tissues. EPR bile flow monitoring (BFM) and blood circulation monitoring (BCM) analysis can monitor the pharmacokinetics and in vivo redox behaviors of nitroxyl radicals in bile (intracellular environment) and blood (extracellular environment). Differences in intracellular and extracellular volumes in redox environments are discussed. Pharmacokinetic profiles of two nitroxyl contrast agents, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (carbamoyl-PROXYL), 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL), in bile and blood of healthy 8-week-old male Wistar rats were monitored by an EPR BFM or BCM method when the rat was breathing 100% O2 or was subcutaneously administrated 0.2 mmol/kg b.w. of ferric citrate. Re-oxidation of hydroxylamines to nitroxyl radicals was caused in bile under 100% O2 breathing, but not in blood. The administration of ferric citrate caused marked re-oxidation in bile, but a slight reduction in blood. Since 100% O2 breathing increased H2O2 concentration in bile, the re-oxidation of hydroxylamines to the corresponding nitroxyl radicals may be partly mediated by intracellular H2O2 generation; however, tissue Fe3+ concentration can work more effectively in the re-oxidation of hydroxylamines. The effects of 100% O2 breathing were larger in bile, while less effect was observed in blood. The intracellular environment is more susceptible to oxidation than the extracellular environment under conditions such as 100% O2 breathing or iron overload. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2010 International Chemical Congress of Pacific Basin Societies | |||||
| 発表年月日 | ||||||
| 日付 | 2010-12-20 | |||||
| 日付タイプ | Issued | |||||
