WEKO3
アイテム
Reduction of C11-FLB 457 (dopamine D2 receptor ligand) binding in medial prefrontal cortex in mature rat with maternal immune activation
https://repo.qst.go.jp/records/70350
https://repo.qst.go.jp/records/703502dcf9a36-598e-4c8c-a593-0614a94fc222
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-02 | |||||
| タイトル | ||||||
| タイトル | Reduction of C11-FLB 457 (dopamine D2 receptor ligand) binding in medial prefrontal cortex in mature rat with maternal immune activation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oh-Nishi, Arata
× Oh-Nishi, Arata× Nagai, Yuji× Suhara, Tetsuya× Obayashi, Shigeru× 大西 新× 永井 裕司× 須原 哲也× 大林 茂 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Major mental disorders such as schizophrenia are characterized by disturbances of thoughts, perception, cognition and volition. It is reported that about 1% of the world population becomes morbid with schizophrenia. However, the schizophrenia pathology and onset mechanism are not well known. Recently, it was reported that dopamine D2 receptor (D2R) binding decreases in the medial prefrontal cortex (mPFC) in schizophrenia patients (Suhara et al 2002). On the other hand, it has been indicated that maternal immune activation increases the risk of psychiatric disorders such as schizophrenia in offspring. This suggests the possibility that maternal immune activation induces disruption of the dopaminergic system, which then leads to schizophrenia pathology in offspring. To test this hypothesis, we gave Toll-like receptor3 ligand synthetic double-stranded RNA polyriboinosinic-polyribocytidilic acid (Poly I:C), which mimics viral infection causing immune activation, to pregnant rats on gestation days 15-18. Then we investigated D2R ligand (C11-labeled FLB457) binding potential in whole brain of mature offspring of Poly I:C-treated dams by positron emission tomography. We found that C11-labeled FLB457 binding potential significantly decreased in mPFC in mature offspring of Poly I:C-treated dams (P<0.05). This result indicates a high degree of homology between the animal model of schizophrenia with maternal immune activation and schizophrenia patients, in terms of disruption of the dopaminergic system. We suggest that maternal immune activation might evoke schizophrenia-like pathology in adulthood. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuroscience 2010, SfN's 40th annual meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2010-11-17 | |||||
| 日付タイプ | Issued | |||||
