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Behavioral characteristics of low motivation and its relation to serotonin in a primate model of depression
https://repo.qst.go.jp/records/70347
https://repo.qst.go.jp/records/70347ce46f855-5ebe-4726-b359-503ef3b77fd9
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-12-02 | |||||
| タイトル | ||||||
| タイトル | Behavioral characteristics of low motivation and its relation to serotonin in a primate model of depression | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Minamimoto, Takafumi
× Minamimoto, Takafumi× Oh-Nishi, Arata× Yukiko, Hori× Nagai, Yuji× Suhara, Tetsuya× 南本 敬史× 大西 新× 堀 由紀子× 永井 裕司× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The motivation to engage in behavior arises from both incentive factors (e.g., size or timing of reward) and drive (e.g., thirst or hunger). Motivation is also affected by mood, which is related to mental or biological states as well. For example, depression is associated with low motivation in general. What is altered in motivational function in the brain in depression? Here we studied motivational alteration in depression with a monkey model of hypothyroidism, which is associated with symptoms, such as fatigue or depression. Three monkeys were injected with antithyroid agent, methimazole (10-100 mg/day), which inhibits production of thyroid hormone. After about a month of application, the thyroxin level became less than half of normal (5 -> 2.5 mu g/dl). We examined the behavioral effect of hypothyroidism by using a reward-size task (Minamimoto et al., 2009). In this task, the monkey earned a reward if it correctly released a bar after a signal changes to green. A visual cue presented at the beginning of each trial indicated the size of the reward (1, 2, 4 or 8 drops) after the correct bar release. In the hypothyroid state, the monkey's error rate went up dramatically without increasing reaction time. To analyze the effect quantitatively, we fitted the data with an inverse function of reward size with 2 free parameters, reward sensitive and reward unrelated terms. We found significant decrease of reward sensitivity (0.6 +/- 0.2 of normal) and increase of reward-unrelated "general errors" of 5.3 +/- 2.8%. Moreover, by application of SSRI (citalopram, 1-8 mg/day), the general error dropped without recovery of reward-size sensitivity. These results suggest that the hypothyroid-induced low motivational state can be characterized by reward desensitization and increase of general error, and that the latter is associated with a low serotonin level. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Neuroscience 2010, SfN's 40th annual meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2010-11-17 | |||||
| 日付タイプ | Issued | |||||
