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Reduction of lung fibrosis after carbon-ion irradiation in Interleukin-6 knock-out mice
https://repo.qst.go.jp/records/70287
https://repo.qst.go.jp/records/70287f868f9e0-d446-4c2b-b6e2-d7ad2c489946
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-25 | |||||
| タイトル | ||||||
| タイトル | Reduction of lung fibrosis after carbon-ion irradiation in Interleukin-6 knock-out mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Hidetoshi
× Fujita, Hidetoshi× Fujita, Tomoko× Iwakawa, Mayumi× Nakamura, Etsuko× Nakawatari, Miyako× Moritake, Takashi× Imai, Takashi× 藤田 英俊× 藤田 知子× 岩川 眞由美× 中村 悦子× 中渡 美也子× 盛武 敬× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is well known that a cyclic cascade of inflammatory cytokines, together with the activation of macrophages, is initiated very early after irradiation for development of lung fibrosis in a late phase. Interleukin-6 (IL-6), one of inflammatory cytokines, is involved in development of lung fibrosis. Although IL-6 is induced by radiation, the role of IL-6 in lung fibrosis caused by radiation was unclear. In this study, we evaluated a role of IL-6 in the late-phase inflammatory response and subsequent fibrotic changes after carbon-ion (c-ion) irradiation using wild-type (WT) and IL-6 knock out (IL-6 KO) mice. The mice underwent thoracic irradiation with 10 Gy of c-ion beam or sham-irradiation and were examined by histology. At 24 weeks after irradiation, the infiltration of macrophages, detected by positive immunohistological staining with Mac3 antibody, was observed in alveolar spaces both in WT and IL-6 KO mice. The thickening of bronchiolar and alveolar walls exhibited in WT mice, but not KO mice, and fibrotic changes, detected by Masson-Trichrome staining, were observed only in the lungs of WT mice, while it was attenuated in IL-6 KO mice. These results indicated that IL-6 plays an important role for fibrotic changes of alveolar wall after irradiation. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 53ｒd Annual Meeting of The Japan Radiation Research Society | |||||
| 発表年月日 | ||||||
| 日付 | 2010-10-22 | |||||
| 日付タイプ | Issued | |||||
