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Diagnostic accuracy of C-11 methionine PET/CT for cervical lymph node metastasis from head and neck cancer: a comparison of histopathological classifications of primary lesions
https://repo.qst.go.jp/records/70284
https://repo.qst.go.jp/records/7028429785385-d000-4a0a-b21a-5be28342132a
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-10-22 | |||||
| タイトル | ||||||
| タイトル | Diagnostic accuracy of C-11 methionine PET/CT for cervical lymph node metastasis from head and neck cancer: a comparison of histopathological classifications of primary lesions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohashi, Seiya
× Ohashi, Seiya× Yoshikawa, Kyosan× Toubaru, Sachiko× Hasebe, Mitsuhiko× Ishikawa, Hiroyuki× Sagou, Kenji× Tamura, Katsumi× Tanimoto, Katsuyuki× Kandatsu, Susumu× Mizoe, Junetsu× Fukumura, Toshimitsu× Saga, Tsuneo× Kawaguchi, Koji× Kamada, Tadashi× 大橋 靖也× 吉川 京燦× 桃原 幸子× 長谷部 充彦× 石川 博之× 田村 克巳× 谷本 克之× 神立 進× 溝江 純悦× 福村 利光× 佐賀 恒夫× 鎌田 正 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE Wesometimes encounter nodular activities in neck area of patients with cancer onwhole body PET/CT using C-11 methionine (MET). However, these nodularactivities are not necessarily the case that they are true metastasis. There isa possibility that the nodular activities may be physiological or inflammatoryaccumulation or depiction of intravascular radioisotope. We evaluateddetectability of MET-PET/CT for neck lymphnode metastasis from primary head andneck cancer, and we compared the difference of diagnostic accuracy amonghistopathological classifications of primary lesions. METHODS AND MATERIALS Wereviewed MET-PET/CT images of 351 studies of head and neck cancer patients,from June 2006 to December 2008, searching for any nodular accumulation in neckarea. We picked 49 patients up with any nodular accumulation in neck area assuspicious candidates for lymphnode metastasis. There were 68 lesions in total.Pathology of primary tumor were squamous cell carcinoma (SCC) in 19 nodules,malignant melanoma (MM) in 18 nodules, adenoid cystic carcinoma (ACC) in 12nodules, and others in 19 nodules. All sites of nodular accumulation wereconfirmed by pathology or by clinical follow-up. We evaluated diagnosticindexes (Sensitivity, Specificity, Accuracy etc.) for all nodules together andfor each histology, and we compared the difference of indexes amonghistopathologies of primary lesions. We use TNR, tumor to normal tissue ratio,to estimate MET accumulation. RESULTS Twenty-seven nodules in 18 patients foundout as metastasis. Fourteen positive nodules were from SCC, four were from MM,one was from ACC, and eight were from other pathological tumors. Each positiveratio was 39.7%, 73.7%, 77.8% and 8.3%, respectively. When we use a cutoff TNRvalue, 2.70 derived from all 68 nodules, to diagnose metastasis, sensitivity,specificity and accuracy for total nodules were 58.6%, 74.4% and 67.7%,respectively. And the three diagnostic indexes using the same cutoff value(2.70 TNR) for SCC, MM and ACC were 64.3%, 100.0%, 73.7%, and 75.0%, 50.0%,55.6%, and 100.0%, 81.8%, 83.3%, respectively. But if we determined cutoffvalues independently for SCC, MM, and ACC, the accuracy were improved to 89.5%,88.9% and 91.7%, respectively. CONCLUSION MET-PET/CT was useful for diagnosisof neck lymphnode metastasis from head and neck cancer, but the cutoff valuefor distinction of metastasis was very important. The cutoff values determinedindependently for histopathological classifications of primary lesions mightimprove the diagnostic accuracy. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 2010 EANM Congress | |||||
| 発表年月日 | ||||||
| 日付 | 2010-10-13 | |||||
| 日付タイプ | Issued | |||||
