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Minマウス消化管における放射線発がん機構の解析
https://repo.qst.go.jp/records/70266
https://repo.qst.go.jp/records/70266872eb03d-9a70-458f-8f29-2b510321ade6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-30 | |||||
| タイトル | ||||||
| タイトル | Minマウス消化管における放射線発がん機構の解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
岡本, 美恵子
× 岡本, 美恵子× 岡本 美恵子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To elucidate the molecular mechanism of radiation tumorigenesis in mice, we generated a mouse strain by substituting an entire chromosome 18 in B6-Min mouse. The strain shows marked increase in intestinal tumors when irradiated at 2-weeks old, while there was almost no excess induction in 7-weeks-old irradiation. To clarify the mechanisms of the age dependency, we performed systemic LOH analysis of chromosome18 in the tumors. Marked difference was found in LOH patterns of spontaneous and radiation-induced tumors; tumors in 2-weeks irradiation group showed intrachromosomal LOH and copy number reduction in the Apc region, while spontaneous tumors showed whole-chromosome loss without copy number reduction. Some tumors in 7-weeks irradiation group showed LOH patterns typically seen in 2-weeks group. This suggests that X-ray exposure had induced DNA lesions in the tumors, presumably in latent form. To test the possibility, we irradiated mice, and with some intervals, administered 1% Dextan Sulfate Sodium (DSS). The combination of X-ray and DSS treatment gave synergistic effects on the colon tumor induction. Possible mechanism of the age dependency will be proposed. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第69回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-24 | |||||
| 日付タイプ | Issued | |||||
