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1H-MRI and 1H-MRS in ferritin transgenic mice
https://repo.qst.go.jp/records/70241
https://repo.qst.go.jp/records/7024172a45152-c88f-4f6d-aae9-3ad18c31d2cb
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-14 | |||||
| タイトル | ||||||
| タイトル | 1H-MRI and 1H-MRS in ferritin transgenic mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Morokoshi, Yukie
× Morokoshi, Yukie× Hasegawa, Sumitaka× Saito, Shigeyoshi× Takanashi, Junichi× Furukawa, Takako× Saga, Tsuneo× Aoki, Ichio× 諸越 幸恵× 長谷川 純崇× 齋藤 茂芳× 高梨 潤一× 古川 高子× 佐賀 恒夫× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Iron homeostasis is tightly regulated by iron-binding proteins, as iron excess exhibits toxicity in cells. Ferritin is an intracellular iron storage protein that plays various roles such as controlling iron concentration in vivo. It is well-known that ferritin is involved in the pathogenesis of some human disorders, for example, aberrant ferritin expression has shown to be involved in neurodegenerative diseases. We generated transgenic (Tg) mice of human ferritin heavy chain (FTH) gene and investigated the effects of ferritin overexpression by 1H-MRI and 1H-MRS. The mice displayed no apparent neurological symptoms, no specific morphological and T2 alterations in the brain were found in MRI, and not even in histological studies.1H-MRS, however, revealed that some metabolic markers were significantly altered in FTH-Tg brains compared to wild-type brains, such as decreases in myo-inositol and glutamine, and an increase in lactate. Our findings provide the evidence that ferritin overexpression affects brain metabolism. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | World Molecular Imaging Congress 2010 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-11 | |||||
| 日付タイプ | Issued | |||||
