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First Imaging Tests of an OpenPET Prototype for Small Animals
https://repo.qst.go.jp/records/70226
https://repo.qst.go.jp/records/7022674e0ad8a-974f-4eb6-8663-c5db78d80cc1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-09-13 | |||||
| タイトル | ||||||
| タイトル | First Imaging Tests of an OpenPET Prototype for Small Animals | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tashima, Hideaki
× Tashima, Hideaki× et.al× 田島 英朗 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: The OpenPET geometry is our new idea to visualize a physically opened space between two detector rings (Yamaya, PMB 757, 2008). The OpenPET is expected to enable 1) PET image-guided radiation therapy by letting the beams pass though the gap, 2) real-time multimodal imaging by inserting another imaging device in the gap, and 3) extension of an axial field-of-view with the limited number of detectors. In this paper, we developed the first prototype for small animals to show a proof-of-concept of OpenPET imaging. Methods: The prototype was designed as a compact system so as to be easily carried between PET areas and therapy areas such as the Heavy Ion Medical Accelerator in Chiba (HIMAC) (figure (a)). Two detector rings of 110 mm in diameter composed of 8 block-detectors were placed with a gap of 42 mm. Actual gap was limited to 27 mm by the gantry structure (but the gap will become over 20 cm, which is enough for radiation therapy, if the gantry is extended to the human size in scale). Each block-detector, which had 4-layer depth-of-interaction capability based on our method (Tsuda, IEEE TNS 2537, 2004), was composed of 2.9 x 2.9 x 5 mm3 LGSO crystals and a Hamamatsu H8500 PMT. Colon-26 cancer cells (2.0 x 10^5) were inoculated subcutaneously into a female BALB/c nude mouse (16.5 g weight) and allowed to grow for 7 days. 18F-FDG (1.6 MBq) was injected intravenously via tail vein. After 70min, the animal was placed so that the tumor located in the gap, and measured for 10 min. For an initial proof-of-concept of real-time multimodal imaging, an optical image of the surface was taken during PET imaging by inserting a digital camera in the gap. Results: As shown in figure (b), the tumor in the gap was clearly visualized. In addition, the large axial FOV of 126 mm was obtained with the detectors originally covering only an 84 mm axial FOV. Conclusion: Our initial imaging studies showed promising performance of the OpenPET prototype. In a molecular imaging field, we expect novel applications of the OpenPET which make the best use of the gap. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2010 World Molecular Imaging Congress | |||||
| 発表年月日 | ||||||
| 日付 | 2010-09-11 | |||||
| 日付タイプ | Issued | |||||
