WEKO3
アイテム
Age dependence of T-cell lymphoma induction by radiation exposure in Mlh1-deficient mice
https://repo.qst.go.jp/records/70191
https://repo.qst.go.jp/records/701919ef0da4f-6f9b-4f93-a0b1-e111b72c01ad
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-07-25 | |||||
| タイトル | ||||||
| タイトル | Age dependence of T-cell lymphoma induction by radiation exposure in Mlh1-deficient mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kakinuma, Shizuko
× Kakinuma, Shizuko× Takimoto, Misaki× Hirano, Shinobu× Nakata, Akifumi× Kodama, Youtarou× Amasaki, Yoshiko× Shang, Yi× Yoshida, Mitsuaki× Nishimura, Mayumi× Shimada, Yoshiya× 柿沼 志津子× 滝本 美咲× 坂入 しのぶ× 中田 章史× 小玉 陽太郎× 甘崎 佳子× 尚 奕× 吉田 光明× 西村 まゆみ× 島田 義也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: The carcinogenic effects of ionizing radiation vary markedly with age and genetic background of exposed individuals, as revealed by epidemiological studies such as the survivors of atomic bomb exposure, Chernobyl accidents and medically irradiated patients. We studied effects of age at exposure on radiation carcinogenesis using mouse model for T-cell lymphomas in mismatch repair (MMR)-deficient mice. Homozygous germline mutations of MMR genes in humans are manifested by an early onset of childhood T- or B-cell leukemias. Materials and methods: Mlh1-deficient mice were irradiated with 2Gy of X-rays at late fetal (17 dpc), 2-weeks and 10-weeks of age, and underwent autopsy at the time of spontaneous death. Collected T-cell lymphomas were examined for the expression and mutation status of Ikaros, which is a potent tumor suppressor for this tumor type in human and mouse. Results: Mlh1-deficient mice develop T-cell lymphomas spontaneously at the incidence of 71%. Ionizing radiation exposure further accelerated lymphoma development; 2-week-old mice were more susceptible to radiation than 10-week-old mice. Radiation-induced lymphoma was characterized by high rate of invasion into other tissues. Unexpectedly, the 17-dpc mice were resistant. When lymphomas were molecularly analyzed, the frame shift mutations at mononucleotide repeat sequences in Ikaros gene were frequently observed, which resulted in loss of the protein. The point mutations in either DNA binding domain or dimerization domain was found in 2-week-old (15%) and 10-week-old (46%) irradiated groups. Conclusion: These results suggest that the age at exposure to ionizing radiation affects not only tumor incidence but also the mechanism of lymphomagenesis. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 21st Meeting of the European Association for Cancer Research | |||||
| 発表年月日 | ||||||
| 日付 | 2010-06-29 | |||||
| 日付タイプ | Issued | |||||
