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DNA copy number changes in radiation-induced mammary carcinoma of (SD x COP) F1 hybrid rats
https://repo.qst.go.jp/records/70186
https://repo.qst.go.jp/records/7018618153698-32d2-484c-83f6-e7e5b1e62844
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-07-20 | |||||
| タイトル | ||||||
| タイトル | DNA copy number changes in radiation-induced mammary carcinoma of (SD x COP) F1 hybrid rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishimura, Mayumi
× Nishimura, Mayumi× Imaoka, Tatsuhiko× Takabatake, Takashi× Daino, Kazuhiro× Kakinuma, Shizuko× Okutani, Tomomi× Takabatake, Masaru× Shimada, Yoshiya× 西村 まゆみ× 今岡 達彦× 高畠 貴志× 臺野 和広× 柿沼 志津子× 奥谷 倫未× 高畠 賢× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Epidemiological studies indicate that breast is one of the most susceptible organs to radiation-induced carcinogenesis. Most studies, however, have failed in identifying clear genetic alterations in radiation-induced breast/mammary cancers. The Copenhagen (COP) rats are completely resistant, whereas Sprague-Dawley (SD) rats are highly susceptible, to chemically-induced mammary carcinogenesis, and this resistance of the COP background is regarded as a dominant trait. Material and Methods: Mammary cancer-prone SD, -resistant COP, and their hybrid (SD x COP) F1 rats were irradiated with gamma-rays at 4 Gy and underwent autopsy at the time of spontaneous death or at 1.5 years post-irradiation. Genomic DNA was extracted from mammary cancers and ear skins of corresponding individuals. Genome-wide DNA copy number was analyzed by array comparative genomic hybridization (aCGH). Results: COP rats were resistant to radiation-induced mammary carcinogenesis. Interestingly, F1 rats showed a relatively susceptible trait, suggesting recessive inheritance of the resistance to radiation-induced mammary carcinogenesis. The preliminary results of aCGH analysis indicated that partial deletions of the proximal region of chromosome 2, where Mcs-1 (mammary cancer susceptibility gene-1 for chemical carcinogenesis) is mapped, were occasionally observed, suggesting a tumor suppressive role of Mcs-1 in radiation carcinogenesis. Other aberrations including small deletions and aneuploidy were also frequent but scattered throughout the genome. Conclusions: These findings implicate that radiation-induced rat mammary cancers are rather heterogeneous with regard to copy number changes. The frequent deletion of COP alleles suggests that these tumor suppressive alleles may be readily targeted by radiation but not carcinogenic chemicals. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 21st Meeting of the European Association for Cancer Research | |||||
| 発表年月日 | ||||||
| 日付 | 2010-06-29 | |||||
| 日付タイプ | Issued | |||||
