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Risk of second malignant neoplasms among childhood cancer survivors treated with radiotherapy: Methological extension of meta-analysis
https://repo.qst.go.jp/records/70181
https://repo.qst.go.jp/records/7018106a10c23-a2f6-469c-adf6-c4af9501b3a3
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-07-14 | |||||
| タイトル | ||||||
| タイトル | Risk of second malignant neoplasms among childhood cancer survivors treated with radiotherapy: Methological extension of meta-analysis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Doi, Kazutaka
× Doi, Kazutaka× Mieno, Makiko× Shimada, Yoshiya× Yonehara, Hidenori× Yoshinaga, Shinji× 土居 主尚× 三重野 牧子× 島田 義也× 米原 英典× 吉永 信治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: Cancer risks following radiotherapy have not well characterized in terms of radiation dose while radiotherapy is recognized as an established risk factor. In our previous meta-analysis of second cancer risks among children who received radiotherapy, the small number of eligible studies precluded detail evaluations. In the current meta-analysis, we developed and applied a method to calculate an ERR estimate from another form of estimates. Methods: We have developed the method to estimate the ERR estimates from the studies in which the relative risk estimates per several dose categories, such as odds ratio, hazard ratio, incidence rate ratio, are available. We fit a linear regression model including radiation dose as a covariate and regard the slope as an ERR estimate. For the estimation of standard error of the ERR estimate, we used the bootstrap method. The overall ERR estimates of radiotherapy were calculated using a random effects model. To validate our method, we compared the ERR estimates from our calculation and from literature where both ERR and the relative risk estimates per several dose categories are available. Results: A total of 23 studies were identified as eligible for meta-analysis through search of PubMed database. ERR estimates were available in 12 studies, and for the rest 11 studies, we calculated a ERR estimate from other estimates. The ERR estimates ranged from 0.004 to 11.7 with the overall ERR of 0.44 (95%CI: 0.22, 0.85), which was far smaller than the corresponding estimate of 1.7 from the study of atomic bomb survivors exposed as young children. Heterogeneity was suggested by Cochran's Q statistics (Q=209, DF=23, p<0.001). There are several possible reasons for the heterogeneity, including cell-killing effect and fractionated exposure. The calculated ERR is not inconsistent with that shown in the article, and the proposed method seems reasonable. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2010 American Statistical Association Conference on Radiation and Health | |||||
| 発表年月日 | ||||||
| 日付 | 2010-06-16 | |||||
| 日付タイプ | Issued | |||||
