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Lymphoma development after In utero exposure to radiation in Mlh1-/- mice
https://repo.qst.go.jp/records/70179
https://repo.qst.go.jp/records/701794b0589f0-f4eb-4c29-87e3-3a1a4c2de4d8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-07-09 | |||||
| タイトル | ||||||
| タイトル | Lymphoma development after In utero exposure to radiation in Mlh1-/- mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takimoto, Misaki
× Takimoto, Misaki× Kakinuma, Shizuko× Amasaki, Yoshiko× Kodama, Youtarou× Takabatake, Takashi× Nishimura, Mayumi× Fukushi, Masahiro× Shimada, Yoshiya× 滝本 美咲× 柿沼 志津子× 甘崎 佳子× 小玉 陽太郎× 高畠 貴志× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Oxford Survey of Childhood Cancers after in utero exposure has demonstrated an increase in childhood lymphoma/leukemia. However, the potential role of radiation in the increase of childhood cancers is still a matter of debate. Moreover, data are insufficient for the cancer risk later in life after in utero exposure. We examined the effect of in utero exposure on lymphoma development using Mlh1-deficient mice which are genetically prone to lymphoma. The survival curves and thymic lymphoma development of non-irradiated and in utero irradiated mice were not significantly different. However, the latency of splenic lymphoma was significantly shortened by in utero exposure. The thymic lymphomas frequently harbored frameshift mutations in Ikaros, a potent tumor suppressor for both human T- and B-cell lymphomas. Surprisingly, the splenic lymphomas showed no mutations in Ikaros. Our results suggest that in utero exposure should be paid more attention especially to persons with mismatch repair-deficient background. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Third Asian and Oceanic Congree on Radiation Protection | |||||
| 発表年月日 | ||||||
| 日付 | 2010-05-28 | |||||
| 日付タイプ | Issued | |||||
