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The effects of carbon-ion irradiation on invasive potential of pancreatic cancer cells, MIAPaCa-2
https://repo.qst.go.jp/records/70114
https://repo.qst.go.jp/records/701148871b25e-c087-4993-944a-21c888bf40be
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-05-26 | |||||
| タイトル | ||||||
| タイトル | The effects of carbon-ion irradiation on invasive potential of pancreatic cancer cells, MIAPaCa-2 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujita, Mayumi
× Fujita, Mayumi× Shoji, Yoshimi× Yamada, Shigeru× Iwakawa, Mayumi× Imai, Takashi× 藤田 真由美× 荘司 好美× 山田 滋× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract: Pancreatic cancer is a highly metastatic tumor with poor response to conventional radiotherapy. C-ion irradiation has advantages compared to conventional photon therapy with accurate dose distribution and higher tumor cell killing, and is expected to improve the clinical outcome for pancreatic cancer patients. The aim of this study was to compare the biological effects of carbon-ion (C-ion) and X-ray irradiation of the invasive pancreatic cancer cell line, MIAPaCa-2. We demonstrated that C-ion irradiation suppresses invasiveness without induction of active MMP-2 compared to conventional X-ray irradiation, which stimulates invasiveness and induces expression of active MMP-2 with enhancing MMP2 transcription. Treatment of cells with an MMP inhibitor diminished X-ray-induced invasiveness but not basal level of invasiveness. We demonstrated that the involvement of inter-convertible mesenchymal and amoeboid modes of motility in the invasiveness of MIAPaCa-2 cells limits the effect of invasiveness of single inhibitors. The use of ROCK inhibitor, in addition to MMP inhibitor, reduced both X-ray-induced and basal level of invasiveness. C-ion irradiation reduced invasiveness much more than these inhibitors and blocked the basal invasiveness of MIAPaCa-2 cells without the use of inhibitors. C-ion irradiation gives higher efficiencies compared to X-ray irradiation in diminishing the invasive potential of MIAPaCa-2 cells. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | PTCOG 49 (49th Annual Meeting of the Particle Therapy Co-Operative Group) | |||||
| 発表年月日 | ||||||
| 日付 | 2010-05-22 | |||||
| 日付タイプ | Issued | |||||
