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Intramolecular Base-Catalysis in the Radical-Scavenging Reaction by Vitamin E Derivatives Bearing a Pyridine Moiety
https://repo.qst.go.jp/records/70087
https://repo.qst.go.jp/records/700875eaa5433-49c2-409f-b2ea-4006443043a5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-05-06 | |||||
| タイトル | ||||||
| タイトル | Intramolecular Base-Catalysis in the Radical-Scavenging Reaction by Vitamin E Derivatives Bearing a Pyridine Moiety | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Yakumaru, Haruko× Nyuui, Minako× Ohkubo, Kei× Matsumoto, Kenichiro× Fukuhara, Kiyoshi× Okuda, Haruhiro× Fukuzumi, Shunichi× Ozawa, Toshihiko× Anzai, Kazunori× Ikota, Nobuo× 中西 郁夫× 薬丸 晴子× 乳井 美奈子× 松本 謙一郎 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to develop effective radioprotectors, we recently synthesized three vitamin E derivatives bearing a pyridine moiety with a linkage of different spacers. All the vitamin E derivatives efficiently scavenged 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical in deaerated methanol at 298 K. The second-order rate constant for DPPH radial-scavenging by one of the vitamin E derivatives determined by the stopped-flow technique is about 3-fold larger than that by 2,2,5,7,8-pentamethylchroman-6-ol, a vitamin E model. This suggests that the pyridine moiety may accelerate the reaction by stabilizing the radical cation generated in the electron transfer from the vitamin E derivative to DPPH radical. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Experimental Biology Annual Meeting 2010 (EB2010) | |||||
| 発表年月日 | ||||||
| 日付 | 2010-04-28 | |||||
| 日付タイプ | Issued | |||||
