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Histopathological studies on chronic mouse hepatitis by natural Helicobacter infection
https://repo.qst.go.jp/records/70080
https://repo.qst.go.jp/records/700806bb9aef7-12a8-49e5-b2c7-331583c020e2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-04-06 | |||||
| タイトル | ||||||
| タイトル | Histopathological studies on chronic mouse hepatitis by natural Helicobacter infection | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nam, Chunja
× Nam, Chunja× Ohmachi, Yasushi× Kokubo, Toshiaki× Nishikawa, Tetsu× Nakayama, Hiroyuki× et.al× 南 春子× 大町 康× 小久保 年章× 西川 哲 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It has been known that Helicobacter hepaticus or Helicobacter bilis infection in mice cause chronic inflammation of the colon and liver. Chronic active hepatitis in mice occurred during carcinogenic study at NIRS in 2005. SPF C3H/HeNrs mice were used for 56~63 week-carcinogenic study by single gamma-ray irradiation. Liver, kidney, Harderian gland, bone marrow and thymus were collected and assessed histological and immunohistochemical examinations. 103 cases among 978 male mice had hepatic lesions. Chronic hepatitis occurred frequently in mice exposed high-dose irradiation compared to non-irradiated mice in one lot. Mild lesions showed only focal necrosis and focal inflammation in the liver. Severe cases were accompanied by hepatocytomegaly, bile duct hyperplasia, hypertrophy and activation of Kupffer cells, cholangitis, pleomorphic hepatocytes and/or tumor. Helical-shaped bacteria were detected between hepatocytes by Warthin-Starry silver stain and immunohistochemistry with an antibody against Helicobacter pyroli. It was suggested that these chronic hepatitis caused by Helicobacter spp. It was also presumed that immunosuppression by irradiation might influence on incidence of chronic hepatitis. Therefore, control of the infection is important for long-term animal study. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第１４９回日本獣医学会 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-03-28 | |||||
| 日付タイプ | Issued | |||||
