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Intramolecular Base-Accelerated Radical-Scavenging Reaction by Vitamin E Derivatives Bearing a Pyridine Moiety
https://repo.qst.go.jp/records/70062
https://repo.qst.go.jp/records/700621b4bfe7d-6715-4a03-8359-77d59ec3b211
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-24 | |||||
| タイトル | ||||||
| タイトル | Intramolecular Base-Accelerated Radical-Scavenging Reaction by Vitamin E Derivatives Bearing a Pyridine Moiety | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Yakumaru, Haruko× Nyuui, Minako× Ohkubo, Kei× Matsumoto, Kenichiro× Fukuhara, Kiyoshi× Okuda, Haruhiro× Fukuzumi, Shunichi× Ozawa, Toshihiko× Anzai, Kazunori× Ikota, Nobuo× 中西 郁夫× 薬丸 晴子× 乳井 美奈子× 松本 謙一郎× 小澤 俊彦× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Fine-tuning of the radical-scavenging activity of antioxidants is of considerable importance with regard to the development of effective chemopreventive agents against oxidative stress and associated diseases. We have reported that the scavenging reaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical by 2,2,5,7,8-pentamethylchroman-6-ol (PMC), a vitamin E model, proceeds via a proton-coupled electron transfer in deaerated methanol (MeOH) and that pyridines significantly accelerate this reaction by stabilizing a radical cation intermediate derived from PMC. In this study, we synthesized three vitamin E derivatives bearing a pyridine moiety with a linkage of different spacers. All the vitamin E derivatives thus obtained efficiently scavenged DPPH radical in deaerated MeOH. The second-order rate constant for the scavenging of DPPH radical by one of the vitamin E derivatives determined by the stopped-flow technique is about 3-fold larger than that by PMC. The scavenging activity of DPPH radical is found to be depending on the length of the spacers. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Oxygen Club of California (OCC) 2010 World Congress | |||||
| 発表年月日 | ||||||
| 日付 | 2010-03-20 | |||||
| 日付タイプ | Issued | |||||
