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Generation of reactive oxygen species by heating aqueous solution containing oxygen

https://repo.qst.go.jp/records/70059
https://repo.qst.go.jp/records/70059
9ec7bcb0-0a2f-44f2-bfc4-bbf1684af1a5
Item type 会議発表用資料 / Presentation(1)
公開日 2010-03-23
タイトル
タイトル Generation of reactive oxygen species by heating aqueous solution containing oxygen
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Matsumoto, Kenichiro

× Matsumoto, Kenichiro

WEKO 687927

Matsumoto, Kenichiro

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Nyuui, Minako

× Nyuui, Minako

WEKO 687928

Nyuui, Minako

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Kamibayashi, Masato

× Kamibayashi, Masato

WEKO 687929

Kamibayashi, Masato

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Ozawa, Toshihiko

× Ozawa, Toshihiko

WEKO 687930

Ozawa, Toshihiko

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Nakanishi, Ikuo

× Nakanishi, Ikuo

WEKO 687931

Nakanishi, Ikuo

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Anzai, Kazunori

× Anzai, Kazunori

WEKO 687932

Anzai, Kazunori

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松本 謙一郎

× 松本 謙一郎

WEKO 687933

en 松本 謙一郎

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乳井 美奈子

× 乳井 美奈子

WEKO 687934

en 乳井 美奈子

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上林 將人

× 上林 將人

WEKO 687935

en 上林 將人

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小澤 俊彦

× 小澤 俊彦

WEKO 687936

en 小澤 俊彦

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中西 郁夫

× 中西 郁夫

WEKO 687937

en 中西 郁夫

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安西 和紀

× 安西 和紀

WEKO 687938

en 安西 和紀

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抄録
内容記述タイプ Abstract
内容記述 Interest for hyperthermia clinical cancer treatment has been increased recently, especially in combination use with existing treatments, i.e. chemotherapy, radiotherapy and immunotherapy to increase efficiency of those treatments. Mechanism for hyperthermal cell killing or sensitization to other stresses/treatments has been unclear. Relation of reactive oxygen species (ROS) to the effect of hyperthermia has been widely alleged and/or reported. Nitroxyl radicals have been conventionally used as chemical redox probe in vitro and in vivo experiments in fields of electron paramagnetic resonance (EPR) spectroscopy. In this presentation, temperature-dependent free radical reactions were investigated using nitroxyl radicals as redox probes. Gluthathione (GSH)-dependent EPR signal loss of nitroxyl radicals occurred temperature-dependently. Details of temperature-dependent reaction of nitroxyl radicals and GSH were investigated. Heating a solution of a hydroxylamine showed EPR signal recovery. Heating a spin trapping agent showed temperature-dependent increase of EPR signal due to the hydroxyl radical adduct. Most of reactions were suppressed by bubbling N2 gas. However, heating carbamoyl-PROXYL with GSH in the N2 gas atmosphere showed temporally enhanced signal decay. Results showed a possibility that heating an aqueous solution containing oxygen can generate O2•-.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 Oxygen Club of California 2010
発表年月日
日付 2010-03-20
日付タイプ Issued
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