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Generation of reactive oxygen species by heating aqueous solution containing oxygen
https://repo.qst.go.jp/records/70059
https://repo.qst.go.jp/records/700599ec7bcb0-0a2f-44f2-bfc4-bbf1684af1a5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-03-23 | |||||
| タイトル | ||||||
| タイトル | Generation of reactive oxygen species by heating aqueous solution containing oxygen | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Kenichiro
× Matsumoto, Kenichiro× Nyuui, Minako× Kamibayashi, Masato× Ozawa, Toshihiko× Nakanishi, Ikuo× Anzai, Kazunori× 松本 謙一郎× 乳井 美奈子× 上林 將人× 小澤 俊彦× 中西 郁夫× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interest for hyperthermia clinical cancer treatment has been increased recently, especially in combination use with existing treatments, i.e. chemotherapy, radiotherapy and immunotherapy to increase efficiency of those treatments. Mechanism for hyperthermal cell killing or sensitization to other stresses/treatments has been unclear. Relation of reactive oxygen species (ROS) to the effect of hyperthermia has been widely alleged and/or reported. Nitroxyl radicals have been conventionally used as chemical redox probe in vitro and in vivo experiments in fields of electron paramagnetic resonance (EPR) spectroscopy. In this presentation, temperature-dependent free radical reactions were investigated using nitroxyl radicals as redox probes. Gluthathione (GSH)-dependent EPR signal loss of nitroxyl radicals occurred temperature-dependently. Details of temperature-dependent reaction of nitroxyl radicals and GSH were investigated. Heating a solution of a hydroxylamine showed EPR signal recovery. Heating a spin trapping agent showed temperature-dependent increase of EPR signal due to the hydroxyl radical adduct. Most of reactions were suppressed by bubbling N2 gas. However, heating carbamoyl-PROXYL with GSH in the N2 gas atmosphere showed temporally enhanced signal decay. Results showed a possibility that heating an aqueous solution containing oxygen can generate O2•-. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Oxygen Club of California 2010 | |||||
| 発表年月日 | ||||||
| 日付 | 2010-03-20 | |||||
| 日付タイプ | Issued | |||||
