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Comparison of Cu-62-ATSM and C-11-Methionine in cancer of the Cervix treated by radiation therapy
https://repo.qst.go.jp/records/69911
https://repo.qst.go.jp/records/699111d369edb-9f68-46e8-aad8-b2317b062e3f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-23 | |||||
| タイトル | ||||||
| タイトル | Comparison of Cu-62-ATSM and C-11-Methionine in cancer of the Cervix treated by radiation therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hasebe, Mitsuhiko
× Hasebe, Mitsuhiko× Yoshikawa, Kyosan× Ohashi, Seiya× Toubaru, Sachiko× Ishikawa, Hiroyuki× Sagou, Kenji× Tamura, Katsumi× Kiyohara, Hiroki× Kato, Shingo× Kandatsu, Susumu× Fukumura, Toshimitsu× Saga, Tsuneo× Kawaguchi, Koji× Tsujii, Hirohiko× 長谷部 充彦× 吉川 京燦× 大橋 靖也× 桃原 幸子× 石川 博之× 田村 克巳× 清原 浩樹× 加藤 眞吾× 神立 進× 福村 利光× 佐賀 恒夫× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose:To determine if Cu-62 labeled diacetyl-bis (N (4)-methylthiosemicarbazone); (Cu-62-ATSM) imaging of tumor hypoxia is associated with C-11-methionine imaging of amino acid metabolism in cervical cancer. The carbon ion radiotherapy (CIRT) has been introduced in our institute, and we have treated cervical cancer using carbon ion beam or intracavitary treatment and whole pelvis irradiation.Cu-62-ATSM has been used clinically as a positron emission tomography (PET) tracer for the delineation of hypoxia. Tumor hypoxia is a critical factor in irradiation of malignant tumor. Method: PET/CT was performed in eighteen patients with cervical cancer for evaluation of both tumor hypoxia using Cu-62-ATSM and amino acid metabolism using C-11-Methionine. Histologically confirmed ten squamous cell carcinoma, five adenocarcima, two Adenosquamous carcinoma and one Malignant melanoma were enrolled in this study. PET/CT studies were underwent before and after treatment. Tumor uptake of each tracer was analyzed semi-quantitatively by Tumor-to-Normal-Tissue-Ratio (TNR). Result: Pretherapeutic mean TNR was 8.7 in C-11-Methionine and 2.9 in Cu-62-ATSM, and thus image contrast between tumor and surrounding normal tissue was higher in C-11-Methionine PET/CT image than in Cu-62-ATSM PET/CT image. Pretherapeutic TNR of both Cu-62-ATSM and C-11-Methionine showed significant difference between squamous cell carcinoma and other tumor group (p=0.0165, p=0.0060, respectively). Posttherapeutic mean TNR was 2.9 in C-11-Methionine and 2.1 in Cu-62-ATSM. Posttherapeutic TNR of either Cu-62-ATSM and C-11-Methionine showed no significant difference between squamous cell carcinoma and other tumor group, respectively. TNR of squamous cell carcinoma in Cu-62-ATSM PET/CT after treatment was significantly lower than pre-therapeutic TNR (p<0.0001). It might imply that squamous cell carcinoma of uterine cervix tended to hypoxic in pre-terapeutic condition and CIRT might improve its hypoxic condition. The improvement of hypoxic condition might be associated with therapeutic effect of CIRT. But there was no significant difference in TNR of other tumor group between pre- and post-therapeutic TNR (p=0.061). Conclusion: Cervical cancer had a greater tendency to incorporate C-11-Methionine than Cu-62-ATSM before any treatment. The improvement of hypoxic condition in squamous cell carcinoma of uterine cervix might be associated with therapeutic effect of CIRT. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 2009 EANM Congress | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-14 | |||||
| 日付タイプ | Issued | |||||
