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Radio-adaptive response in normal human cells induced by protons
https://repo.qst.go.jp/records/69877
https://repo.qst.go.jp/records/6987763c069b1-e7ae-4f3e-b60a-e7d175e58318
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-06 | |||||
| タイトル | ||||||
| タイトル | Radio-adaptive response in normal human cells induced by protons | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suzuki, Masao
× Suzuki, Masao× Tsuruoka, Chizuru× Hua, Liu Cui× 鈴木 雅雄× 鶴岡 千鶴× 劉 翠華 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The radio-adaptive response refers to the phenomenon by which cells irradiated with a sub-lethal dose of ionizing radiation (priming dose) become less sensitive to subsequent irradiation with high doses (challenging dose). Recently we reported that the mutation frequency at hprt locus in normal human cells induced by the X-ray challenging dose was reduced at 0.15 times in cells pre-treated with low-dose-rate neutrons (1mSv/8h) as a priming dose compared to unpre-treated cells, but the reduced mutation frequency was returned to the control level, when using a specific inhibitor of gap-junction mediated cell-cell communication. We set up a hypothesis that recoiled protons emitted by the interaction between neutrons and cells / water induce radio-adaptive response in irradiated cell population via gap-junction mediated bystander effect. To examine the hypothesis around 1.5% of cells were irradiated with one proton before irradiating the X-ray challenging dose using proton microbeams accelerated with the Single Particle Irradiation system to Cell (SPICE) in National Institute of Radiological Sciences. The result clearly showed that the X-ray induced mutation frequency was suppressed in cells pre-treated with proton microbeams and returned to the control level, when using a specific inhibitor of gap-junction mediated cell-cell communication. The result suggests that neutron-induced adaptive response is caused by recoiled protons and gap-junction mediated bystander effect plays an important role to induce such cellular response. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 日本宇宙生物科学会第23回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-04 | |||||
| 日付タイプ | Issued | |||||
