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One-Step Hydrogen Atom Transfer in Radical-Scavenging Reactions by Artepillin C Derivatives Enhanced by Electron-Donating Groups
https://repo.qst.go.jp/records/69614
https://repo.qst.go.jp/records/696141afba43f-e11a-4182-ac0e-f5fda282dfc2
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-12-01 | |||||
| タイトル | ||||||
| タイトル | One-Step Hydrogen Atom Transfer in Radical-Scavenging Reactions by Artepillin C Derivatives Enhanced by Electron-Donating Groups | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakanishi, Ikuo
× Nakanishi, Ikuo× Ohkubo, Kei× Uto, Yoshihiro× Kawashima, Tomonori× Manda, Sushma× Fukuhara, Kiyoshi× Okuda, Haruhiro× Hori, Hitoshi× Ikota, Nobuo× Fukuzumi, Shunichi× Ozawa, Toshihiko× Anzai, Kazunori× 中西 郁夫× Ｍａｎｄａ Ｓｕｓｈｍａ× 小澤 俊彦× 安西 和紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Artepillin C, a major component of Brazilian propolis, is a prenylated phenylpropanoid, which shows efficient antioxidative activities. In this study, we synthesized novel artepillin C derivatives in order to enhance the radical-scavenging activity of natural antioxidants. The scavenging rate constants of DPPH (2,2-diphenyl-1-picrylhydrazyl) radical determined by the stopped-flow technique indicate that the introduction of the electron-donating groups on the benzene ring significantly decreases the enthalpy of the phenolic O-H bond dissociation, resulting in the enhancement of the radical-scavenging activities of the artepillin C derivatives. There results suggested that the radical-scavenging reactions of the artepillin C derivatives proceed via one-step hydrogen atom transfer rather than proton-coupled electron transfer. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 15th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM) | |||||
| 発表年月日 | ||||||
| 日付 | 2008-11-23 | |||||
| 日付タイプ | Issued | |||||
