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悪性中皮腫の非侵襲的画像診断法のためのＰＥＴとレーサーの比較検討
https://repo.qst.go.jp/records/69560
https://repo.qst.go.jp/records/695601898a14d-44a8-410f-b861-927fa7e0f0d5
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-31 | |||||
| タイトル | ||||||
| タイトル | 悪性中皮腫の非侵襲的画像診断法のためのＰＥＴとレーサーの比較検討 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
辻, 厚至
× 辻, 厚至× 曽川, 千鶴× 須藤, 仁美× 小泉, 満× 樋野, 興夫× 原田, 良信× 佐賀, 恒夫× 辻 厚至× 曽川 千鶴× 須藤 仁美× 小泉 満× 原田 良信× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Malignant pleural mesothelioma (MPM) is a highly aggressive tumor and the prognosis with current treatment remains poor. Thus, development of more effective treatments has been required. Noninvasive imaging is essential for assessment of the efficacy of new treatment. To establish noninvasive imaging for MPM, we compared tumor uptake of three PET tracers, [F-18]-FDG, [F-18]-FLT and [C-11]-thiothymidine. We established subcutaneous and orthotopic models of epithelioid and sarcomatoid MPM in mice, and conducted biodistribution study and PET imaging. Two thymidine analogues, FLT and thiothymidine, highly accumulated in epithelioid MPM, while glucose analogue, FDG, highly accumulated in sarcomatoid MPM. Then, we measured in vitro cellular uptake of FDG and FLT and the cytosolic thymidine kinase 1 (TK1) activity of each cell line. Uptake of both FDG and FLT in sarcomatoid MPM was higher than that in epithelioid MPM, and the TK1 activity of sarcomatoid was higher than epithelioid MPM, indicating in vitro characters are not always consistent with in vivo behavior. Our results suggest that the suitable PET tracer is different for the evaluation of epithelioid and sarcomatoid MPM. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第67回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-10-30 | |||||
| 日付タイプ | Issued | |||||
