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Difference in bystander cell-killing effect between normal and tumor cells irradiated with carbon-ion beams.
https://repo.qst.go.jp/records/69558
https://repo.qst.go.jp/records/695582222fa08-6b50-4f83-a3b3-f1bd31b76af1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-31 | |||||
| タイトル | ||||||
| タイトル | Difference in bystander cell-killing effect between normal and tumor cells irradiated with carbon-ion beams. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suzuki, Masao
× Suzuki, Masao× Tsuruoka, Chizuru× Furusawa, Yoshiya× 鈴木 雅雄× 鶴岡 千鶴× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Since 1994, a Phase I/II clinical study and cancer radiotherapy have been begun using carbon-ion beams generated with the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences. In the field of fundamental biological studies for high-LET radiations, there are many reports regarding bystander cellular effects after exposure to alpha particles derived from 238Pu or He-ion microbeams. However, only limited sets of studies have examined bystander effects after exposure to different ion species heavier than helium, such as carbon ions. In this study we has been investigating bystander cellular responses in both normal human fibroblasts and a human tumor cell line irradiated with low energy (6MeV/n) carbon ions generated with the Medium Energy Beam Course at the HIMAC. Cells were inoculated onto the Mylar film in the dishes and then irradiated with 6MeV/n carbon ions at a fluence of 1.5 x 105 particles/cm2. Cells were exposed using 4 different protocols; (1) Cells were irradiated with all of the cells on the Mylar film; (2) Cells were irradiated with half of the cell population on the Mylar film; (3) Irradiated cells and un-irradiated control cells were pooled in a 1:1 ratio and plated as a single culture; and (4) Half of the cells were irradiated and treated with a specific inhibitor of gap-junction mediated cell-cell communication (40µM lindane). Cell killing in normal human cells, which was assayed with a colony formation assay, showed that the surviving fraction of the irradiated group (2) was almost the same as for group (1). In addition, a similar level of survival was seen between in the group (4) and in the group (3). However, no bystander cell-killing effect was observed in a human tumor cell line. There is evidence that the different bystander cellular effects induced by carbon ions occurred in between normal and tumor cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第67回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-10-30 | |||||
| 日付タイプ | Issued | |||||
