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ベータ-アミロイド産生マウスを用いたベータ−アミロイドリガンド[11C]PIBの結合機序の解明
https://repo.qst.go.jp/records/69509
https://repo.qst.go.jp/records/69509f486ee20-788d-46a2-9acf-47e8e1516df6
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-08 | |||||
| タイトル | ||||||
| タイトル | ベータ-アミロイド産生マウスを用いたベータ−アミロイドリガンド[11C]PIBの結合機序の解明 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
前田, 純
× 前田, 純× 樋口, 真人× 須原, 哲也× 前田 純× 樋口 真人× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In vivo neuromolecular imaging technology has been markedly reinforced by application of positron emission tomography (PET) to genetically engineered animal models of neuropsychiatric disorders, by taking advantages of this imaging modality in quantitative reconstruction of signals and flexible designing of specific probes. On this basis, we provide the first evidence for the capability of a high-resolution PET imaging system in quantitatively mapping amyloid accumulation in living amyloid precursor protein transgenic (Tg) mice. It is also noteworthy that the localization and abundance of [11C]PIB autoradiographic signals were closely associated with those of N-terminally truncated and modified Abeta, AbetaN3-pyroglutamate, in Alzheimer's disease (AD) and Tg mouse brains, implying that the detectability of amyloid by [11C]PIB positron emission tomography is dependent on the accumulation of specific Abetasubtypes. Our results support the usefulness of the small animal-dedicated PET system in conjunction with high-specific radioactivity probes and appropriate Tg models not only for clarifying the mechanistic properties of amyloidogenesis in mouse models. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 生体機能と創薬シンポジウム 2008 東京 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-09-06 | |||||
| 日付タイプ | Issued | |||||
