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Stable chromosome aberrations in the lymphocytes of the residents in different areas: A large city, and a high background radiatioon area and its control area in China.
https://repo.qst.go.jp/records/69485
https://repo.qst.go.jp/records/69485f4a1de42-2ff0-4d72-a7e6-d6a666768d17
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-29 | |||||
| タイトル | ||||||
| タイトル | Stable chromosome aberrations in the lymphocytes of the residents in different areas: A large city, and a high background radiatioon area and its control area in China. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Chun, Yan Wang
× Chun, Yan Wang× Zhang, Wei× Minamihisamatsu, Masako× Luxin, Wei× Sugahara, Tsutomu× Hayata, Isamu× 王 春燕× 張 偉× 南久松 眞子× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have reported in our previous papers that the frequencies of dicentrics and rings significantly increase in the high background radiation area (HBRA) in China, but the increase of the frequencies of translocations (Tr) is invisible (Hayata et al., 2004) . The level of natural radiation in HBRA is 3 - 5 times higher than that in control area (CA). Present study includes new data of the analysis of Tr in the residents in a large city, Beijing, where people are exposed to a lot of environmental mutagenic stresses including air polluting factors. The frequency of the Tr in the lymphocytes of non-smokers who live in Beijing for longer than 40 years is compared with those of non-smokers in HBRA and CA, remote villages, in China. The blood was taken from 20, 16, and 16 non-smokers in Beijing, HBRA and CA, respectively. Their average ages were 61.2, 64.1 and 64.4 years old, respectively. The blood of children in HBRA (12.3 years old on average) and in CA (12.5 years old on average) were also collected. Individual radiation dose was measured with a pocket dose meter (Aloka PDM-10) put on the body for 24 hours. The lymphocytes were cultured for 48 hours with PHA and Colcemide, and harvested according to the standard method. Tr were analyzed by the chromosome painting method using whole chromosome painting probes for #1, #2, and #4. Total number of metaphases analyzed was 213,876 (4,113 per resident). Statistical analysis was done by the Mann-Witteney's U test. Genomic frequencies of Tr in 1,000 cells per adult were 9.6+/-5.0, 12.8+/-6.4 and 8.4+/-3.1 in Beijing, HBRA and CA, respectively. The frequencies in child were 3.8+/-1.1 in HBRA and 3.2+/-2.0 in CA. Individual variation was large in adult and small in child. It is demonstrated that the frequencies of Tr in the lymphocytes well reflect the individual difference in the amount of mutagenic factors taken into each human body. There is a statistically significant difference (p<0.05) in the frequencies of Tr between child and adult, and between HBRA and CA in adult, but there is no significant difference between other comparable groups. Thus the effect of the elevated level of natural radiation in HBRA becomes obscure when the frequencies of Tr are compared between the residents in HBRA and those in a metropolis where people are incessantly exposed to a lot of environmental mutagenic stresses including air pollutants. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
