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Effect of smoking reflected in the stable chromosome aberrations in the lymphocytes of the residents in the areas exposed to different environmental mutagens including radiation.
https://repo.qst.go.jp/records/69484
https://repo.qst.go.jp/records/6948420250899-aea8-4353-9df2-fdc44dbfee69
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-29 | |||||
| タイトル | ||||||
| タイトル | Effect of smoking reflected in the stable chromosome aberrations in the lymphocytes of the residents in the areas exposed to different environmental mutagens including radiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Wei
× Zhang, Wei× Chun, Yan Wang× Minamihisamatsu, Masako× Luxin, Wei× Sugahara, Tsutomu× Hayata, Isamu× 張 偉× 王 春燕× 南久松 眞子× 早田 勇 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Smoking is the most influential factor among the environmental mutagens to increase cancer incidence. Previously we reported that the effect of smoking on the induction of chromosome aberration in the residents in high background radiation area (HBRA) was larger than that of the elevated level of natural radiation in China (Zhang et al., 2004). In order to know how environmental mutagens affect the induction of translocations caused by smoking we analyzed the translocations in the lymphocytes of smokers in a large city, Beijing, and compared them with those in a high background radiation area (HBRA) and in its control area (CA), remote villages, in South China. The studied residents in Beijing have lived there for longer than 40 years. The level of natural radiation in HBRA is 3 - 5 times higher than those in CA and in Beijing. The residents in remote villages (HBRA and CA) mainly smoke the shredded tobaccos through a water pipe instead of the cigarette which is common in Beijing. Individual radiation dose was measured with a pocket dose meter (Aloka PDM-10) put on the body for 24 hours. Peripheral blood was obtained from 5, 10, and 7 smokers in Beijing, HBRA and CA, respectively. Their ages were around 60 years old. Peripheral lymphocytes were cultured for 48 hours with PHA and colcemide, and harvested according to our standard method for biodosimetry. Chromosomes #1, #2, and #4 were painted for the analysis of translocations. The number of metaphases analyzed was totally 90,267 (4,103 per resident). Statistical analysis was done by Mann-Witteney's U test. Genomic frequencies of translocation in 1,000 lymphocytes per smoker are 8.7+/-3.0, 11.1+/-3.6 and 13.4+/-3.4 in Beijing, HBRA and CA, respectively. Standard deviation is similar among three groups. CA group shows the highest average value among three groups. There was a statistically significant difference (p>0.05) in the frequencies of translocation between the smokers in Beijing and those in CA, but no other possible comparisons between groups showed significant difference. The effect of smoking seems to be suppressed by the environmental mutagens including the elevated level of natural radiation in HBRA. Further study is in progress to see if such suppression effect is statistically significant or not. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 13th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2007-07-12 | |||||
| 日付タイプ | Issued | |||||
