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Development of anti-ERC/mesothelin antibody probe for PET/SPECT imaging of Malignant Mesothelioma

https://repo.qst.go.jp/records/69460
https://repo.qst.go.jp/records/69460
1a8b6269-f2d1-497a-98be-09c62ee868a3
Item type 会議発表用資料 / Presentation(1)
公開日 2008-09-19
タイトル
タイトル Development of anti-ERC/mesothelin antibody probe for PET/SPECT imaging of Malignant Mesothelioma
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_c94f
資源タイプ conference object
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Sogawa, Chizuru

× Sogawa, Chizuru

WEKO 681681

Sogawa, Chizuru

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Tsuji, Atsushi

× Tsuji, Atsushi

WEKO 681682

Tsuji, Atsushi

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Sugyou, Aya

× Sugyou, Aya

WEKO 681683

Sugyou, Aya

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Sudou, Hitomi

× Sudou, Hitomi

WEKO 681684

Sudou, Hitomi

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Furukawa, Takako

× Furukawa, Takako

WEKO 681685

Furukawa, Takako

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Koizumi, Mitsuru

× Koizumi, Mitsuru

WEKO 681686

Koizumi, Mitsuru

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Harada, Yoshinobu

× Harada, Yoshinobu

WEKO 681687

Harada, Yoshinobu

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Saga, Tsuneo

× Saga, Tsuneo

WEKO 681688

Saga, Tsuneo

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et.al

× et.al

WEKO 681689

et.al

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曽川 千鶴

× 曽川 千鶴

WEKO 681690

en 曽川 千鶴

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辻 厚至

× 辻 厚至

WEKO 681691

en 辻 厚至

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須尭 綾

× 須尭 綾

WEKO 681692

en 須尭 綾

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須藤 仁美

× 須藤 仁美

WEKO 681693

en 須藤 仁美

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古川 高子

× 古川 高子

WEKO 681694

en 古川 高子

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小泉 満

× 小泉 満

WEKO 681695

en 小泉 満

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原田 良信

× 原田 良信

WEKO 681696

en 原田 良信

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佐賀 恒夫

× 佐賀 恒夫

WEKO 681697

en 佐賀 恒夫

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抄録
内容記述タイプ Abstract
内容記述 Mesothelioma is an aggressive tumor arising from serosal surfaces of the pleura and peritoneum closely related to asbestos exposure. This is a rare tumor, but the incidence is increasing worldwide over the next several decades because of high consumption of asbestos. Although the prognosis of patients with current treatments remains poor, that of patients at an early stage has been reported to be improved. Thus, the diagnosis at the early stage of mesothelioma is necessary for the better prognosis. However, current diagnostic modalities including FDG-PET are difficult to detect the early stage of mesothelioma, and it is essential to develop a new diagnostic method for detection at the early stage. The ERC/Mesothelin (ERC) is a cell surface glycoprotein and is strongly expressed in epithelioid subtype of mesothelioma. The primary product of ERC is a 71-kDa precursor protein, which is cleaved into a 40-kDa C-terminal fragment that remains membrane-bound and a 31-kDa N-terminal fragment that is secreted into the blood. Since the antibody against the C-terminal fragment is very useful for distinguishing pleural mesotheliomas from adenocarcinomas and squamous cell carcinomas of the lung by immunohistochemistry, the radiolabeled antibody recognizing C-terminal fragment could be used for in vivo imaging of ERC-positive mesotheliomas. In this study, we radiolabeled anti-ERC antibody with 125I and 111In, and performed cell binding, competitive inhibition and internalization assays in vitro using a human mesothelioma cell line, H226, highly expressing ERC primarily localized to the cell membrane. We also performed biodistribution and SPECT imaging in vivo using tumor-bearing mice. These results showed that the radiolabeled antibody specifically bound to ERC expressing cells and were weakly internalized, and the 111In-labeled antibody highly accumulated in the xenografted tumor, which was readily visualized by SPECT. The radiolabeled anti-ERC antibody would be useful for the PET/SPECT imaging of malignant mesothelioma.
会議概要(会議名, 開催地, 会期, 主催者等)
内容記述タイプ Other
内容記述 World Molecular Imaging Congress
発表年月日
日付 2008-09-13
日付タイプ Issued
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